PMID- 20673590
OWN - NLM
STAT- MEDLINE
DCOM- 20100917
LR  - 20220409
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 117
IP  - 9
DP  - 2010 Sep
TI  - High-resolution imaging of resolved central serous chorioretinopathy using 
      adaptive optics scanning laser ophthalmoscopy.
PG  - 1800-9, 1809.e1-2
LID - 10.1016/j.ophtha.2010.01.042 [doi]
AB  - OBJECTIVE: To compare pathologic changes in photoreceptors in eyes with resolved 
      central serous chorioretinopathy (CSC) seen on high-resolution images obtained by 
      adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) 
      and findings on spectral-domain optical coherence tomography (SD OCT). DESIGN: 
      Observational case series. PARTICIPANTS: Forty-five eyes of 38 patients with 
      resolved CSC and 20 normal eyes of 20 volunteer subjects. METHODS: All patients 
      underwent a full ophthalmologic examination, SD OCT, and imaging with an original 
      prototype AO SLO system fabricated using liquid crystal-on-silicon technology. 
      MAIN OUTCOME MEASURES: Cone mosaic patterns and cone density on AO SLO images and 
      VA in eyes with CSC. RESULTS: In normal eyes, AO SLO images showed a regular 
      photoreceptor mosaic pattern and average cone densities 0.2, 0.5, and 1.0 mm from 
      the central fovea of 67,900, 33,320, and 14,450 cones/mm(2). In eyes with CSC, 
      cone densities were significantly lower at each distance from the central fovea 
      (P = 0.009 at 0.2 mm, P = 0.007 at 0.5 mm, and P = 0.004 at 1.0 mm), and 2 
      distinct cone mosaic patterns were seen. Group 1 CSC eyes had regular cone mosaic 
      patterns with small dark regions. Group 2 CSC eyes had irregular mosaic patterns 
      with large dark regions. Compared with group 1, group 2 had significantly lower 
      average cone density and worse average logarithm of the minimum angle of 
      resolution (logMAR) VA (P<0.001). Mean cone density in eyes with disruptions in 
      the photoreceptor inner and outer segment (IS/OS) junction or in the intermediate 
      line on SD OCT images was significantly lower than that in eyes with an intact 
      IS/OS junction or intermediate line (P<0.001 for both). Cone density 0.2 mm from 
      the central fovea correlated with logMAR VA and mean foveal thickness (1-mm 
      diameter area) measured on SD OCT images (P<0.001 for both). CONCLUSIONS: 
      Adaptive optics SLO images showed abnormal cone mosaic patterns and reduced cone 
      densities in eyes with resolved CSC, and these abnormalities were associated with 
      VA loss, suggesting that AO SLO is a useful means to detect and measure cone 
      abnormalities associated with VA loss in these eyes.
CI  - Copyright (c) 2010 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Ooto, Sotaro
AU  - Ooto S
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan. ohoto@kuhp.kyotou.ac.jp
FAU - Hangai, Masanori
AU  - Hangai M
FAU - Sakamoto, Atsushi
AU  - Sakamoto A
FAU - Tsujikawa, Akitaka
AU  - Tsujikawa A
FAU - Yamashiro, Kenji
AU  - Yamashiro K
FAU - Ojima, Yumiko
AU  - Ojima Y
FAU - Yamada, Yoshihiko
AU  - Yamada Y
FAU - Mukai, Hideo
AU  - Mukai H
FAU - Oshima, Susumu
AU  - Oshima S
FAU - Inoue, Takashi
AU  - Inoue T
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100729
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Count
MH  - Central Serous Chorioretinopathy/*diagnosis/physiopathology/therapy
MH  - Coloring Agents
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green
MH  - Laser Coagulation
MH  - Male
MH  - Middle Aged
MH  - *Ophthalmoscopy
MH  - Photochemotherapy
MH  - Retinal Cone Photoreceptor Cells/*pathology
MH  - Tomography, Optical Coherence
MH  - Vision Disorders/physiopathology
MH  - Visual Acuity/physiology
EDAT- 2010/08/03 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/08/03 06:00
PHST- 2009/08/26 00:00 [received]
PHST- 2010/01/16 00:00 [revised]
PHST- 2010/01/25 00:00 [accepted]
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - S0161-6420(10)00115-6 [pii]
AID - 10.1016/j.ophtha.2010.01.042 [doi]
PST - ppublish
SO  - Ophthalmology. 2010 Sep;117(9):1800-9, 1809.e1-2. doi: 
      10.1016/j.ophtha.2010.01.042. Epub 2010 Jul 29.