PMID- 20674204
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20110913
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 80
IP  - 1
DP  - 2011 Oct
TI  - High-resolution phase-contrast MRI of aortic and pulmonary blood flow during rest 
      and physical exercise using a MRI compatible bicycle ergometer.
PG  - 103-8
LID - 10.1016/j.ejrad.2010.06.045 [doi]
AB  - PURPOSE: To establish high-resolution phase-contrast magnetic resonance imaging 
      (PC-MRI) using a MRI compatible bicycle ergometer to quantify aortic and 
      pulmonary blood flow during resting conditions and exercise. MATERIALS AND 
      METHODS: In 20 healthy volunteers (mean age, 26.8+/-5.0 years) high-resolution 
      PC-MRI (mean temporal resolution, 7.4+/-3.2 ms) was performed in the ascending 
      aorta (AA) and main pulmonary artery (PA) during physical rest and three exercise 
      stages: stage 1, no-load operation; stage 2, heart rate increase 40% compared to 
      rest; stage 3, heart rate increase 80% compared to rest. Flow quantification in 
      AA and PA included flow volume (FV), average velocity (AV), peak velocity (PV) 
      and time to PV (TP). RESULTS: In stage 1 only TP demonstrated a significant 
      change. With progression to stage 2, all parameters altered significantly. Flow 
      measurements during stage 3 evidenced further alterations only of AV and TP 
      regarding both AA and PA. The deviation of the heart rate from the desired target 
      value was significantly higher for stage 3 compared to stage 2, and 15% of the 
      subjects did not reach the desired target heart rate of stage 3 at all. 
      CONCLUSION: Flow quantification by high-resolution PC-MRI during exercise using a 
      MRI compatible bicycle ergometer is feasible. Medium exercise stages are 
      necessary and sufficient to demonstrate flow alterations in healthy volunteers. 
      PC-MRI ergometry may give insights into aberrant hemodynamic conditions in 
      patients with cardiovascular and pulmonary disease.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Weber, Tim Frederik
AU  - Weber TF
AD  - Department of Diagnostic and Interventional Radiology, University Medical Center 
      Heidelberg, INF 110, 69120 Heidelberg, Germany. tim.weber@med.uni-heidelberg.de
FAU - von Tengg-Kobligk, Hendrik
AU  - von Tengg-Kobligk H
FAU - Kopp-Schneider, Annette
AU  - Kopp-Schneider A
FAU - Ley-Zaporozhan, Julia
AU  - Ley-Zaporozhan J
FAU - Kauczor, Hans-Ulrich
AU  - Kauczor HU
FAU - Ley, Sebastian
AU  - Ley S
LA  - eng
PT  - Journal Article
DEP - 20100731
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adult
MH  - Aorta/*physiology
MH  - *Blood Flow Velocity
MH  - Exercise/*physiology
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - *Pulmonary Circulation
EDAT- 2010/08/03 06:00
MHDA- 2012/01/19 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/06/22 00:00 [revised]
PHST- 2010/06/25 00:00 [accepted]
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - S0720-048X(10)00321-9 [pii]
AID - 10.1016/j.ejrad.2010.06.045 [doi]
PST - ppublish
SO  - Eur J Radiol. 2011 Oct;80(1):103-8. doi: 10.1016/j.ejrad.2010.06.045. Epub 2010 
      Jul 31.