PMID- 20674211
OWN - NLM
STAT- MEDLINE
DCOM- 20101203
LR  - 20151119
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 53
IP  - 4
DP  - 2010 Dec 1
TI  - New coated SPME fibers for extraction and fast HPLC determination of selected 
      drugs in human blood.
PG  - 1022-7
LID - 10.1016/j.jpba.2010.07.002 [doi]
AB  - Polythiophene (PTh) and polypyrrole (PPy) as sorbent phases for solid phase 
      microextraction (SPME) were applied in order to extract the multi-resistant 
      Staphylococcus aureus (MRSA) antibiotic drugs (linezolid and daptomycin) from 
      whole blood followed by high performance liquid chromatography (HPLC) 
      determination with UV detection. Relative standard deviations (RSDs) of in vitro 
      and pseudo in vivo measurements performed in whole blood were in the range of 
      4.58-15.91% and 6.09-17.33% for linezolid and daptomycin, respectively. 
      Determination coefficients (R(2)) were in range of 0.9884-0.9945 and 
      0.9807-0.9818 for linezolid and daptomycin, respectively. This study proved 
      better adsorption capacity of PTh SPME coating compared to PPy coating for both, 
      linezolid and daptomycin.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Olszowy, Pawel
AU  - Olszowy P
AD  - Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, 
      Nicolaus Copernicus University, Gagarin 7, Torun, Poland.
FAU - Szultka, Malgorzata
AU  - Szultka M
FAU - Fuchs, Patricia
AU  - Fuchs P
FAU - Kegler, Ricarda
AU  - Kegler R
FAU - Mundkowski, Ralf
AU  - Mundkowski R
FAU - Miekisch, Wolfram
AU  - Miekisch W
FAU - Schubert, Jochen
AU  - Schubert J
FAU - Buszewski, Boguslaw
AU  - Buszewski B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100802
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Acetamides)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Oxazolidinones)
RN  - 0 (Polymers)
RN  - 0 (Pyrroles)
RN  - 0 (Thiophenes)
RN  - 25233-34-5 (polythiophene)
RN  - 30604-81-0 (polypyrrole)
RN  - ISQ9I6J12J (Linezolid)
RN  - NWQ5N31VKK (Daptomycin)
SB  - IM
MH  - Acetamides/*blood
MH  - Anti-Bacterial Agents/*blood
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Daptomycin/*blood
MH  - Humans
MH  - Linezolid
MH  - Oxazolidinones/*blood
MH  - Polymers/chemistry
MH  - Pyrroles/chemistry
MH  - Solid Phase Microextraction/*methods
MH  - Thiophenes/chemistry
EDAT- 2010/08/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2009/12/31 00:00 [received]
PHST- 2010/06/24 00:00 [revised]
PHST- 2010/07/03 00:00 [accepted]
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0731-7085(10)00363-8 [pii]
AID - 10.1016/j.jpba.2010.07.002 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2010 Dec 1;53(4):1022-7. doi: 10.1016/j.jpba.2010.07.002. 
      Epub 2010 Aug 2.