PMID- 20674387
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20220409
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Linking)
VI  - 21
IP  - 11
DP  - 2010 Nov
TI  - Retinoid X receptors: common heterodimerization partners with distinct functions.
PG  - 676-83
LID - 10.1016/j.tem.2010.06.009 [doi]
AB  - Retinoid X receptors (RXRs) have been implicated in a diversity of cellular 
      processes ranging from cellular proliferation to lipid metabolism. These 
      pleiotropic effects stem not only from the ability of RXRs to dimerize with 
      diverse nuclear receptors, which exert transcriptional control on specific 
      aspects of cell biology, but also because binding of RXR ligands to heterodimers 
      can stimulate transcriptional activation by RXR partner receptors. This signaling 
      network is rendered more complex by the existence of different RXR isotypes 
      (RXRalpha, RXRbeta, RXRgamma) with distinct properties that thereby modulate the 
      transcriptional activity of RXR-containing heterodimers. This review discusses 
      the emerging roles of RXR isotypes in the RXR signaling network and possible 
      implications for our understanding of nuclear receptor biology and pharmacology.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Lefebvre, Philippe
AU  - Lefebvre P
AD  - Universite du Droit et de la Sante de Lille - Nord de France.
FAU - Benomar, Yacir
AU  - Benomar Y
FAU - Staels, Bart
AU  - Staels B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100730
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Retinoid X Receptors)
SB  - IM
MH  - Humans
MH  - Models, Biological
MH  - Models, Molecular
MH  - Protein Binding/physiology
MH  - Protein Multimerization/genetics/*physiology
MH  - Retinoid X Receptors/chemistry/genetics/*metabolism/*physiology
MH  - Substrate Specificity
MH  - Transcriptional Activation/genetics/*physiology
EDAT- 2010/08/03 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/05/14 00:00 [received]
PHST- 2010/06/25 00:00 [revised]
PHST- 2010/06/29 00:00 [accepted]
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - S1043-2760(10)00120-7 [pii]
AID - 10.1016/j.tem.2010.06.009 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2010 Nov;21(11):676-83. doi: 10.1016/j.tem.2010.06.009. 
      Epub 2010 Jul 30.