PMID- 20676943
OWN - NLM
STAT- MEDLINE
DCOM- 20110428
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 1
DP  - 2011 Mar
TI  - Therapeutic potentials of mesenchymal stem cells derived from human umbilical 
      cord.
PG  - 195-207
LID - 10.1007/s12015-010-9168-8 [doi]
AB  - Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), isolated from 
      discarded extra-embryonic tissue after birth, are promising candidate source of 
      mesenchymal stem cells (MSCs). Apart from their prominent advantages in abundant 
      supply, painless collection, and faster self-renewal, hUC-MSCs have shown the 
      potencies to differentiate into a variety of cells of three germ layers (such as 
      bone, cartilage, adipose, skeletal muscle, cardiomyocyte, endothelium, 
      hepatocyte-like cluster, islet-like cluster, neuron, astrocyte and 
      oligodendrocyte), to synthesize and secret a set of trophic factors and 
      cytokines, to support the expansion and function of other cells (like 
      hematopoietic stem cells, embryonic stem cells, natural killer cells, islet-like 
      cell clusters, neurons and glial cells), to migrate toward and home to 
      pathological areas, and to be readily transfected with conventional methods. Two 
      excellent previous reviews documenting the characteristics of this cell 
      population with special emphasis on its niche, isolation, surface markers and 
      primitive properties have been published recently. In this review, we will 
      firstly give a brief introduction of this cell population, and subsequently dwell 
      on the findings of differential capacities with emphasis on its therapeutic 
      potentials.
FAU - Fan, Cun-Gang
AU  - Fan CG
AD  - Neurosurgical Department of Peking University People's Hospital, Beijing, China.
FAU - Zhang, Qing-jun
AU  - Zhang QJ
FAU - Zhou, Jing-ru
AU  - Zhou JR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Disease
MH  - Humans
MH  - Immunomodulation
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology/metabolism
MH  - Umbilical Cord/*cytology
EDAT- 2010/08/03 06:00
MHDA- 2011/04/29 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/04/29 06:00 [medline]
AID - 10.1007/s12015-010-9168-8 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Mar;7(1):195-207. doi: 10.1007/s12015-010-9168-8.