PMID- 20677160
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 27
IP  - 4
DP  - 2010 Aug
TI  - [Association of the TGF-beta1 gene polymorphisms and blood TGF-beta 1 level with 
      essential hypertension in Kazakh Chinese].
PG  - 463-8
LID - 10.3760/cma.j.issn.1003-9406.2010.04.024 [doi]
AB  - OBJECTIVE: To investigate the association of the transforming growth factor- beta 
      1 (TGF- beta 1) gene polymorphisms and blood TGF- beta 1 level with essential 
      hypertension (EH) in Kazakh Chinese. METHODS: The polymorphisms of TGF- beta 1 
      gene in 354 Kazakh EH patients and 435 healthy controls were detected with 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and 
      DNA sequencing. The blood level of TGF- beta 1 was quantified using specific 
      sandwich ELISA. RESULTS: The frequencies of genotypes GG, GC and alleles G and C 
      of +915G/C in Xinjiang Kazakh were 97.9%, 2.1% and 98.77%, 1.23%, respectively. 
      No significantly difference was found between EH patients and controls (P>0.05). 
      The frequencies of genotypes TT, TC, CC and alleles T and C of +869T/C in 
      controls was 25.97%, 46.67%, 27.36%, 49.3% and 50.7%, respectively, the CC 
      genotype or C allele in EH patients had significantly higher frequencies than 
      controls [41.60% vs. 27.36%, and 62.2% vs. 50.7%, respectively (P<0.05)]. It was 
      also shown that TGF- beta 1 +869 C allele carriers had significantly increased 
      risk of EH compared with T allele carriers (OR=1.60, P=0.00). There was linkage 
      disequilibrium (LD) between the two polymorphisms. The frequency of haplotype C-G 
      in the EH group was significantly higher than that in controls (61.6% vs. 49.8%, 
      P<0.05). There were no differences in TGF- beta 1 level among different genotypes 
      or alleles in both +869T/C and +915G/C loci (P>0.05). CONCLUSION: The frequency 
      of +915G/C variation of the TGF- beta 1 gene was very low in Kazakh and there was 
      no homozygous variation. The +869 C allele was likely the genetic susceptibility 
      factor for EH in the population. There was linkage disequilibrium in the 
      polymorphisms of +869T/C and +915G/C. Haplotype C-G was the risk factor of EH.
FAU - Zhao, Dan
AU  - Zhao D
AD  - Department of Pathophysiology/Key Laboratory of Xinjiang Endemic and Ethnic 
      Diseases, Ministry of Education of China, Shihezi University School of Medicine, 
      Shihezi, Xinjiang, 832002 PR China.
FAU - Hu, Qing-hua
AU  - Hu QH
FAU - Deng, Feng-mei
AU  - Deng FM
FAU - Zhong, Hua
AU  - Zhong H
FAU - Guo, Shu-xia
AU  - Guo SX
FAU - Shi, Xiao-peng
AU  - Shi XP
FAU - Yang, Jian-feng
AU  - Yang JF
FAU - He, Fang
AU  - He F
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/*ethnology/genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Hypertension/epidemiology/*genetics
MH  - Linkage Disequilibrium/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Transforming Growth Factor beta1/*genetics
EDAT- 2010/08/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 940627070 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2010.04.024 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Aug;27(4):463-8. doi: 
      10.3760/cma.j.issn.1003-9406.2010.04.024.