PMID- 20678352
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20170214
IS  - 1591-0199 (Print)
IS  - 1591-0199 (Linking)
VI  - 3
IP  - 2
DP  - 1997 Jun 30
TI  - Sticky Platelet Syndrome: a Cause of Neurovascular Thrombosis and 
      Thrombo-embolism.
PG  - 145-54
AB  - Increased platelet aggregation induced by adenosine diphosphate and epinephrine 
      and enhanced platelet activation response to surface contact are the key features 
      of the "sticky platelet syndrome", in which the phenotype is transmitted with an 
      autosomal dominant pattern. Two thirds of the patients with this syndrome have a 
      positive family history of thrombo-embolic disease, which may be triggered by 
      stress. We have seen two patients suffering from intracranial arterial and venous 
      sinus thrombosis due to sticky platelet syndrome. Hyperaggregability of the 
      platelets after stimulation with adenosine diphosphate and epinephrine was found 
      in both. Case 1: A 43 year old man with a superior sagittal and right transverse 
      venous sinus thrombosis developed subdural hygromas and a venous infarct of the 
      parietal lobe. After burr hole evacuation of the hygromas, aspirin and 
      phenoprocumone were prescribed. The patient made a good neurological recovery. 
      Case 2: A 52 year old woman experienced spontaneous occlusion of a right MCA 
      branch. The work-up revealed bilateral MCA and a basilar tip aneurysm. During the 
      attempt to treat the basilar tip aneurysm by endovascular means, a thrombus 
      formed within the left vertebral artery and was dislodged to both posterior 
      cerebral arteries (PCAs). Local intra-arterial fibrinolysis yielded good 
      recanalization of both PCAs. No new neurological deficit occurred. Continuous 
      prophylaxis with aspirin was started. In sticky platelet syndrome stress and 
      adrenaline release can trigger the thrombosis of intracranial arterial or venous 
      vessels in otherwise healthy subjects. This is a potential cause of 
      thromboembolic complications during endovascular procedures. Low-dose aspirin 
      normalizes platelet hyperaggregability.
FAU - Berg-Dammer, E
AU  - Berg-Dammer E
AD  - Departments of Neuroradiology and Neurology, Alfried Krupp Krankenhaus; Essen, 
      Germany.
FAU - Henkes, H
AU  - Henkes H
FAU - Trobisch, H
AU  - Trobisch H
FAU - Kuhne, D
AU  - Kuhne D
LA  - eng
PT  - Journal Article
DEP - 20010515
PL  - United States
TA  - Interv Neuroradiol
JT  - Interventional neuroradiology : journal of peritherapeutic neuroradiology, 
      surgical procedures and related neurosciences
JID - 9602695
EDAT- 1997/06/30 00:00
MHDA- 1997/06/30 00:01
CRDT- 2010/08/04 06:00
PHST- 1997/04/12 00:00 [received]
PHST- 1997/04/18 00:00 [accepted]
PHST- 2010/08/04 06:00 [entrez]
PHST- 1997/06/30 00:00 [pubmed]
PHST- 1997/06/30 00:01 [medline]
AID - IN.v3.i2.p145 [pii]
AID - 10.1177/159101999700300206 [doi]
PST - ppublish
SO  - Interv Neuroradiol. 1997 Jun 30;3(2):145-54. doi: 10.1177/159101999700300206. 
      Epub 2001 May 15.