PMID- 20678718
OWN - NLM
STAT- MEDLINE
DCOM- 20100827
LR  - 20220330
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 121
IP  - 9
DP  - 2010 Sep
TI  - Cognitive effects of topiramate revealed by standardised low-resolution brain 
      electromagnetic tomography (sLORETA) of event-related potentials.
PG  - 1494-1501
LID - S1388-2457(10)00301-9 [pii]
LID - 10.1016/j.clinph.2010.03.013 [doi]
AB  - OBJECTIVE: To evaluate the effect of topiramate (TPM) on event-related potentials 
      (ERPs) in patients with epilepsy. METHODS: Neuropsychological tests and ERP study 
      using auditory oddball paradigm were conducted before and after treatment with 
      TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP 
      changed during the cognitive task, cortical current densities of ERP components 
      were analysed using standardised low-resolution electromagnetic tomography 
      (sLORETA). RESULTS: Neuropsychological tests (n=18 patients) showed that TPM 
      significantly decreased the score in digit span, Corsi block and Controlled Oral 
      Word Association word fluency. Repeated-measures analysis of variance of ERP data 
      (n=13 patients) revealed that P2 amplitude was significantly increased at Fz 
      electrode following treatment with TPM. Statistical non-parametric map of sLORETA 
      between pre- and post-TPM ERPs revealed that current density of P200 component 
      was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic 
      and dorsolateral right prefrontal regions. CONCLUSIONS: Our findings suggest that 
      TPM affects selective brain regions which may be related to cognitive side 
      effects. SIGNIFICANCE: Source localisation of ERPs can be helpful in identifying 
      target brain regions for the cognitive side effects of anti-epileptic drugs.
CI  - 2010 International Federation of Clinical Neurophysiology. Published by Elsevier 
      Ireland Ltd. All rights reserved.
FAU - Jung, Ki-Young
AU  - Jung KY
AD  - Department of Neurology, Korea University Medical Center, Korea University 
      College of Medicine, Seoul, South Korea.
FAU - Cho, Jae-Wook
AU  - Cho JW
AD  - Department of Neurology, Yangsan Pusan National University School of Medicine, 
      Busan, South Korea.
FAU - Joo, Eun Yeon
AU  - Joo EY
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, South Korea.
FAU - Kim, Sun Hwa
AU  - Kim SH
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, South Korea.
FAU - Choi, Kyung Mook
AU  - Choi KM
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, South Korea.
FAU - Chin, Juhee
AU  - Chin J
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, South Korea.
FAU - Park, Kun-Woo
AU  - Park KW
AD  - Department of Neurology, Korea University Medical Center, Korea University 
      College of Medicine, Seoul, South Korea.
FAU - Hong, Seung Bong
AU  - Hong SB
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, South Korea. Electronic address: sbhong@skku.edu.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
RN  - 0 (Anticonvulsants)
RN  - 0H73WJJ391 (Topiramate)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/*pharmacology/therapeutic use
MH  - Brain/*drug effects/physiopathology
MH  - Brain Mapping
MH  - Cognition/*drug effects
MH  - Epilepsy/drug therapy/pathology/physiopathology
MH  - Evoked Potentials/*drug effects
MH  - Female
MH  - Fructose/*analogs & derivatives/pharmacology/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Reaction Time/drug effects
MH  - Statistics, Nonparametric
MH  - Topiramate
MH  - Young Adult
EDAT- 2010/08/04 06:00
MHDA- 2010/08/28 06:00
CRDT- 2010/08/04 06:00
PHST- 2008/08/11 00:00 [received]
PHST- 2010/02/19 00:00 [revised]
PHST- 2010/03/09 00:00 [accepted]
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/08/28 06:00 [medline]
AID - S1388-2457(10)00301-9 [pii]
AID - 10.1016/j.clinph.2010.03.013 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2010 Sep;121(9):1494-1501. doi: 10.1016/j.clinph.2010.03.013.