PMID- 20679736
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 74
IP  - 10
DP  - 2010 Oct
TI  - Beneficial effects of adaptive servo ventilation in patients with chronic heart 
      failure.
PG  - 2118-24
AB  - BACKGROUND: Sleep-disordered breathing (SDB) is thought to be a state of 
      inflammation caused by hypoxic stress. Whether adaptive servo ventilation (ASV) 
      attenuates the inflammatory response and improves the cardiac function of 
      patients with congestive heart failure (CHF) accompanied by SDB was not been 
      investigated. METHODS AND RESULTS: Seventeen inpatients with New York Heart 
      Association (NYHA) II or III underwent polysomnography. There was a positive 
      correlation between the apnea hypopnea index and high-sensitivity C-reactive 
      protein (hs-CRP) level (r=0.753, P=0.016). The patients were divided into ASV 
      (n=10) and non-ASV groups (n=7), and CHF-parameters were measured before and 
      after ASV treatment. Improvement was noted for the NYHA class in the ASV group 
      but not in the non-ASV group. In contrast to the non-ASV group, the level of 
      brain natriuretic peptide (BNP), ejection fraction, and hs-CRP levels in the ASV 
      group significantly improved (BNP, 212.1 +/- 181.2 to 77.3 +/- 54.0 pg/ml [P<0.05]; 
      ejection fraction, 43.5 +/- 6.4 to 53.3 +/- 6.1% [P=0.002]; hs-CRP, 0.85 +/- 0.58 to 
      0.21 +/- 0.19 mg/dl, [P=0.008]). The increase in ejection fraction was correlated 
      with a decrease in the hs-CRP level (r=-0.753, P=0.001). CONCLUSIONS: 
      Anti-inflammatory effects of ASV are important contributors for improving cardiac 
      function in patients with CHF accompanied by SDB. 
FAU - Koyama, Takashi
AU  - Koyama T
AD  - Department of Cardiovascular and Respiratory Medicine, Akita University Graduate 
      School of Medicine, Akita, Japan.
FAU - Watanabe, Hiroyuki
AU  - Watanabe H
FAU - Kobukai, Yusuke
AU  - Kobukai Y
FAU - Makabe, Shin
AU  - Makabe S
FAU - Munehisa, Yoshiko
AU  - Munehisa Y
FAU - Iino, Kenji
AU  - Iino K
FAU - Kosaka, Toshimitsu
AU  - Kosaka T
FAU - Ito, Hiroshi
AU  - Ito H
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20100729
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
CIN - Circ J. 2010 Oct;74(10):2056-7. PMID: 20838005
MH  - Aged
MH  - C-Reactive Protein/analysis
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Inflammation
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Polysomnography
MH  - *Positive-Pressure Respiration
MH  - Sleep Apnea Syndromes/*congenital/*therapy
MH  - Treatment Outcome
EDAT- 2010/08/04 06:00
MHDA- 2011/02/24 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
AID - JST.JSTAGE/circj/CJ-10-0082 [pii]
AID - 10.1253/circj.cj-10-0082 [doi]
PST - ppublish
SO  - Circ J. 2010 Oct;74(10):2118-24. doi: 10.1253/circj.cj-10-0082. Epub 2010 Jul 29.