PMID- 2068202
OWN - NLM
STAT- MEDLINE
DCOM- 19910813
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 38
IP  - 3
DP  - 1991 Mar
TI  - Haloperidol attenuates conditioned place preferences produced by electrical 
      stimulation of the medial prefrontal cortex.
PG  - 645-50
AB  - A Conditioned Place Preference test procedure [Ettenberg and Duvauchelle (13)] 
      was used to investigate the effects of dopamine antagonist challenge on the 
      rewarding properties of medial prefrontal cortex (MPFC) electrical stimulation. 
      Rats exhibited strong preferences for the side of a two-compartment test 
      apparatus in which they experienced sessions of experimenter-administered 0.5-s 
      trains of MPFC sine-wave 60-Hz stimulation. Pretreatment with the neuroleptic 
      dopamine antagonist drug, haloperidol (0.0, 0.15, or 0.3 mg/kg IP), resulted in a 
      dose-dependent reduction in the magnitude of observed place preferences. 
      Preference tests were conducted 24 hours after drug-conditioning trials and, 
      hence, were not subject to motoric or other nonspecific actions of the 
      neuroleptic treatments. In a control experiment, haloperidol did not block the 
      place aversions produced by dorsomedial tegmental stimulation. Animals can, 
      therefore, recall place-associations formed in the presence of haloperidol, a 
      result which challenges "state-dependent learning" explanations of the drug's 
      actions. Together, these results are consistent with the view that dopamine 
      neurotransmission is involved in the rewarding consequences of electrical 
      stimulation in the medial prefrontal cortex.
FAU - Duvauchelle, C L
AU  - Duvauchelle CL
AD  - Department of Psychology, University of California, Santa Barbara 93106.
FAU - Ettenberg, A
AU  - Ettenberg A
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Animals
MH  - Choice Behavior/*drug effects/physiology
MH  - Conditioning, Classical/*drug effects/physiology
MH  - Electric Stimulation
MH  - Frontal Lobe/*drug effects/physiology
MH  - Haloperidol/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reward
MH  - Self Stimulation/*drug effects/physiology
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 0091-3057(91)90027-Y [pii]
AID - 10.1016/0091-3057(91)90027-y [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1991 Mar;38(3):645-50. doi: 
      10.1016/0091-3057(91)90027-y.