PMID- 20682604
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20211020
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 26
IP  - 3
DP  - 2011 Mar
TI  - Inflammation, kidney function and albuminuria in the Framingham Offspring cohort.
PG  - 920-6
LID - 10.1093/ndt/gfq471 [doi]
AB  - BACKGROUND: Inflammation and chronic kidney disease (CKD) are both associated 
      with cardiovascular disease (CVD). Whether inflammatory biomarkers are associated 
      with kidney function and albuminuria after accounting for traditional CVD risk 
      factors is not completely understood. METHODS: The sample comprised Framingham 
      Offspring cohort participants (n = 3294, mean age 61, 53% women) who attended the 
      seventh examination cycle (1998-2001). Inflammatory biomarkers [C-reactive 
      protein (CRP), tumour necrosis factor (TNF)-alpha, interleukin-6, TNF receptor 2 
      (TNFR2), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant 
      protein-1 (MCP-1), P-selectin, CD-40 ligand, osteoprotegerin, urinary 
      isoprostanes, myeloperoxidase and fibrinogen] were measured on fasting blood 
      samples. Serum creatinine-based estimated glomerular filtration rate (eGFR) and 
      serum cystatin C concentration were used to assess kidney function. Urinary 
      albumin-to-creatinine ratio (UACR) was used to assess albuminuria. Linear or 
      logistic regression was used to test associations between biomarkers and kidney 
      measures. RESULTS: Chronic kidney disease (CKD), defined as eGFR < 59/64 
      mL/min/1.73 m(2) in women/men, was present in 8.8% (n = 291) of participants. 
      TNF-alpha, interleukin-6, TNFR2, MCP-1, osteoprotegerin, myeloperoxidase and 
      fibrinogen were higher among individuals with CKD; all biomarkers except for 
      urinary isoprostanes were elevated in higher cystatin C quartiles; and TNF-alpha, 
      interleukin-6, TNFR2, ICAM-1 and osteoprotegerin were elevated in higher UACR 
      quartiles-all assessed after multivariable adjustment. Almost 6% and 17% of 
      variability in TNFR2 were explained by CKD status and higher cystatin C 
      quartiles, respectively. CONCLUSIONS: Biomarkers of inflammation are associated 
      with kidney function and albuminuria. In particular, substantial variability in 
      soluble TNFR2 is explained by CKD and cystatin C.
FAU - Upadhyay, Ashish
AU  - Upadhyay A
AD  - Division of Nephrology, Tufts Medical Center and Tufts University School of 
      Medicine, Boston, MA, USA. aupadhyay@tuftsmedicalcenter.org
FAU - Larson, Martin G
AU  - Larson MG
FAU - Guo, Chao-Yu
AU  - Guo CY
FAU - Vasan, Ramachandran S
AU  - Vasan RS
FAU - Lipinska, Izabella
AU  - Lipinska I
FAU - O'Donnell, Christopher J
AU  - O'Donnell CJ
FAU - Kathiresan, Sekar
AU  - Kathiresan S
FAU - Meigs, James B
AU  - Meigs JB
FAU - Keaney, John F Jr
AU  - Keaney JF Jr
FAU - Rong, Jian
AU  - Rong J
FAU - Benjamin, Emelia J
AU  - Benjamin EJ
FAU - Fox, Caroline S
AU  - Fox CS
LA  - eng
GR  - R01 HL043302-10/HL/NHLBI NIH HHS/United States
GR  - N01 HC025195/HC/NHLBI NIH HHS/United States
GR  - R01-HL-64753/HL/NHLBI NIH HHS/United States
GR  - K24-DK080140/DK/NIDDK NIH HHS/United States
GR  - R01 HL064753-01/HL/NHLBI NIH HHS/United States
GR  - K24 DK080140/DK/NIDDK NIH HHS/United States
GR  - R01-HL04334/HL/NHLBI NIH HHS/United States
GR  - R01 AG028321/AG/NIA NIH HHS/United States
GR  - R01 HL076784-01/HL/NHLBI NIH HHS/United States
GR  - R01 AG028321-01/AG/NIA NIH HHS/United States
GR  - N01-HC-25195/HC/NHLBI NIH HHS/United States
GR  - R01-HL-076784/HL/NHLBI NIH HHS/United States
GR  - R01-HL70139/HL/NHLBI NIH HHS/United States
GR  - R01 HL076784/HL/NHLBI NIH HHS/United States
GR  - AG028321/AG/NIA NIH HHS/United States
GR  - K24 DK080140-01/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100803
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Biomarkers)
RN  - 0 (Cystatin C)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Albuminuria/*etiology
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Creatinine/urine
MH  - Cystatin C/blood
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Inflammation/*blood/etiology/urine
MH  - Kidney Failure, Chronic/complications/*diagnosis/*physiopathology
MH  - Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC3108344
EDAT- 2010/08/05 06:00
MHDA- 2011/09/09 06:00
PMCR- 2012/03/01
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - gfq471 [pii]
AID - 10.1093/ndt/gfq471 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2011 Mar;26(3):920-6. doi: 10.1093/ndt/gfq471. Epub 2010 
      Aug 3.