PMID- 20683499
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20240323
IS  - 2008-823X (Electronic)
IS  - 1028-852X (Print)
IS  - 1028-852X (Linking)
VI  - 14
IP  - 1-2
DP  - 2010 Jan-Apr
TI  - Effects of active constituents of Crocus sativus L., crocin on 
      streptozocin-induced model of sporadic Alzheimer's disease in male rats.
PG  - 59-65
AB  - BACKGROUND: The involvement of water-soluble carotenoids, crocins, as the main 
      and active components of Crocus sativus L. extract in learning and memory 
      processes has been proposed. In the present study, the effect of crocins on 
      sporadic Alzheimer's disease induced by intracerebroventricular (icv) 
      streptozocin (STZ) in male rats was investigated. METHODS: Male adult Wistar rats 
      (n = 90 and 260-290 g) were divided into 1, control; 2 and 3, crocins (15 and 30 
      mg/kg); 4, STZ; 5 and 6, STZ + crocins (15 and 30 mg/kg) groups. In Alzheimer's 
      disease groups, rats were injected with STZ-icv bilaterally (3 mg/kg) in first 
      day and 3 days later, a similar STZ-icv application was repeated. In STZ + crocin 
      animal groups, crocin was applied in doses of 15 and 30 mg/kg, i.p., one day 
      pre-surgery and continued for three weeks. Prescription of crocin in each dose 
      was repeated once for two days. However, the learning and memory performance was 
      assessed using passive avoidance paradigm, and for spatial cognition evaluation, 
      Y-maze task was used. RESULTS: It was found out that crocin (30 mg/kg)-treated 
      STZ-injected rats show higher correct choices and lower errors in Y-maze than 
      vehicle-treated STZ-injected rats. In addition, crocin in the mentioned dose 
      could significantly attenuated learning and memory impairment in treated 
      STZ-injected group in passive avoidance test. CONCLUSION: Therefore, these 
      results demonstrate the effectiveness of crocin (30 mg/kg) in antagonizing the 
      cognitive deficits caused by STZ-icv in rats and its potential in the treatment 
      of neurodegenerative diseases such as Alzheimer's disease.
FAU - Khalili, Mohsen
AU  - Khalili M
AD  - Dept. of Physiology, Shahed University of Medical Sciences, Tehran, Iran. 
      najafabady@yahoo.com
FAU - Hamzeh, Faezeh
AU  - Hamzeh F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Iran
TA  - Iran Biomed J
JT  - Iranian biomedical journal
JID - 9814853
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Plant Extracts)
RN  - 36-88-4 (Carotenoids)
RN  - 5W494URQ81 (Streptozocin)
RN  - 877GWI46C2 (crocin)
SB  - IM
MH  - Alzheimer Disease/chemically induced/*drug therapy
MH  - Animals
MH  - Antibiotics, Antineoplastic/toxicity
MH  - Avoidance Learning/drug effects
MH  - Body Weight/drug effects
MH  - Carotenoids/*pharmacology
MH  - Cognition Disorders/chemically induced/drug therapy
MH  - Crocus/*chemistry
MH  - Disease Models, Animal
MH  - Injections, Intraventricular
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/drug effects
MH  - Motor Activity/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin/toxicity
PMC - PMC3878147
EDAT- 2010/08/05 06:00
MHDA- 2011/02/11 06:00
PMCR- 2010/01/01
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - ibj-14-059 [pii]
PST - ppublish
SO  - Iran Biomed J. 2010 Jan-Apr;14(1-2):59-65.