PMID- 20683549
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20211020
IS  - 1528-3658 (Electronic)
IS  - 1076-1551 (Print)
IS  - 1076-1551 (Linking)
VI  - 16
IP  - 11-12
DP  - 2010 Nov-Dec
TI  - Interleukin-1beta and interleukin-6 in arthritis animal models: roles in the early 
      phase of transition from acute to chronic inflammation and relevance for human 
      rheumatoid arthritis.
PG  - 552-7
LID - 10.2119/molmed.2010.00067 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is the major target of the therapeutic approach 
      in rheumatoid arthritis. A key issue in the approach to chronic arthritis is the 
      understanding of the crucial molecules driving the transition from the acute 
      phase to the chronic irreversible phase of the disease. In this review we 
      analyzed five experimental arthritis animal models (antigen-induced arthritis, 
      adjuvant-induced arthritis, streptococcal cell wall arthritis, collagen-induced 
      arthritis and SKG) considered as possible scenarios to facilitate interpretation 
      of the biology of human rheumatoid arthritis. The SKG model is strictly dependent 
      on interleukin (IL)-6. In the other models, IL-1beta and IL-6, more than TNF-alpha, 
      appear to be relevant in driving the transition, which suggests that these should 
      be the targets of an early intervention to stop the course toward the chronic 
      form of the disease.
FAU - Ferraccioli, Gianfranco
AU  - Ferraccioli G
AD  - Division of Rheumatology, School of Medicine, Catholic University of the Sacred 
      Heart, Rome, Italy. gf.ferraccioli@rm.unicatt.it
FAU - Bracci-Laudiero, Luisa
AU  - Bracci-Laudiero L
FAU - Alivernini, Stefano
AU  - Alivernini S
FAU - Gremese, Elisa
AU  - Gremese E
FAU - Tolusso, Barbara
AU  - Tolusso B
FAU - De Benedetti, Fabrizio
AU  - De Benedetti F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100802
PL  - England
TA  - Mol Med
JT  - Molecular medicine (Cambridge, Mass.)
JID - 9501023
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/immunology/*pathology
MH  - Arthritis, Infectious/*pathology
MH  - Arthritis, Rheumatoid/*pathology
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Humans
MH  - *Inflammation
MH  - Interleukin-1beta/immunology/*metabolism
MH  - Interleukin-6/immunology/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Tumor Necrosis Factor-alpha/immunology/metabolism
PMC - PMC2972398
EDAT- 2010/08/05 06:00
MHDA- 2011/02/18 06:00
PMCR- 2010/11/01
CRDT- 2010/08/05 06:00
PHST- 2010/05/31 00:00 [received]
PHST- 2010/07/30 00:00 [accepted]
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - molmed.2010.00067 [pii]
AID - 10_67_ferraccioli [pii]
AID - 10.2119/molmed.2010.00067 [doi]
PST - ppublish
SO  - Mol Med. 2010 Nov-Dec;16(11-12):552-7. doi: 10.2119/molmed.2010.00067. Epub 2010 
      Aug 2.