PMID- 20683619
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20220317
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 25
IP  - 11
DP  - 2010 Nov
TI  - Urinary monocyte chemoattractant protein-1 correlates with disease activity in 
      lupus nephritis.
PG  - 2283-8
LID - 10.1007/s00467-010-1605-z [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) has a pathogenic role in murine lupus 
      nephritis (LN). We recruited 25 pediatric and adolescent systemic lupus 
      erythematosus (SLE) patients from our lupus clinic [13 (52%) patients with LN and 
      12 (48%) lupus non-nephritis patients] and evaluated their urinary and plasma 
      MCP-1 levels compared to adult and childhood controls. The median age and SLE 
      disease duration of patients were 14.4 and 5.5 years, respectively. LN patients 
      had a higher median renal (p=0.01) British Isles Lupus Assessment Group (BILAG) 
      index, with a tendency for higher total BILAG scores (p=0.2). There were 
      significantly increased urinary MCP-1 levels in the LN patients compared to 
      healthy controls (p<0.001) whose values were significantly higher than lupus 
      non-nephritis children (p<0.004). Urinary MCP-1 levels correlated well with total 
      BILAG scores (r=0.82, p=0.04). There were no differences in plasma MCP-1 levels 
      between SLE patient groups and pediatric controls, although the levels in the 
      childhood controls were elevated compared to those of the adult controls 
      (p<0.04). These results provide evidence of increased urinary--but not 
      plasma--MCP-1 levels in children with LN, which correlates well with SLE disease 
      activity as measured by the BILAG index.
FAU - Marks, Stephen D
AU  - Marks SD
AD  - Nephro-Urology Unit, University College London Institute of Child Health, 30 
      Guilford Street, London, WC1N 1EH, UK. s.marks@ich.ucl.ac.uk
FAU - Shah, Vanita
AU  - Shah V
FAU - Pilkington, Clarissa
AU  - Pilkington C
FAU - Tullus, Kjell
AU  - Tullus K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100805
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Chemokine CCL2)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Albuminuria/urine
MH  - Animals
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*urine
MH  - Child
MH  - Cohort Studies
MH  - Creatinine/urine
MH  - Female
MH  - Humans
MH  - Kidney/physiopathology
MH  - Lupus Erythematosus, Systemic/blood/*urine
MH  - Lupus Nephritis/blood/*urine
MH  - Male
MH  - Mice
MH  - Severity of Illness Index
EDAT- 2010/08/05 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/05/24 00:00 [received]
PHST- 2010/07/01 00:00 [accepted]
PHST- 2010/06/27 00:00 [revised]
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 10.1007/s00467-010-1605-z [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2010 Nov;25(11):2283-8. doi: 10.1007/s00467-010-1605-z. Epub 
      2010 Aug 5.