PMID- 20684489
OWN - NLM
STAT- MEDLINE
DCOM- 20110215
LR  - 20160325
IS  - 1898-2263 (Electronic)
IS  - 1232-1966 (Linking)
VI  - 17
IP  - 1
DP  - 2010
TI  - Genetic aspect of venom allergy: association with HLA class I and class II 
      antigens.
PG  - 119-23
AB  - Stings from bees and wasps can cause systemic allergic reactions in sensitized 
      patients. However, the mystery of why some cases develop allergic reactions while 
      others do not, remains poorly understood. We investigated whether particular 
      human leukocyte antigen (HLA) class I and class II genes contribute to the 
      development of venom allergy. A total of 21 bee and/or wasp venom sensitive 
      patients who had life-threatening allergic symptoms after a sting, and positive 
      diagnostic tests (Group 1), were included in the study. Thiry-seven healthy 
      subjects without venom allergy (Group 2) were selected as the control group. HLA 
      -class I (A-C) and class II (DR, DQ, DP ) typing was performed by PCR-based 
      techniques. HLA -B*18 and HLA -Cw*07 alleles was found more frequently in Group1 
      than in Group 2 (14.3 percent vs 2.7 percent, p=0.026, and 31 percent vs 14.9 
      percent, p=0.036, respectively). Furthermore, HLA -A*01 allele frequency had a 
      trend to be higher in Group 1 than in Group 2 (14.3 percent vs 4.1 percent, 
      p=0.055). However, the frequencies of HLA -A*03 and HLA -Cw*03 alleles were 
      increased in Group 2 compared to Group 1 (20.3 percent vs 7.1 percent, p=0.049 
      and 10.8 percent vs 0 percent, p=0.024, respectively). Among HLA -class II 
      genotypes, HLA -DQB1*03 allele was significantly increased in Group 2 (60.9 
      percent vs 38.1 percent, p=0.018), while a higher frequency of HLA -DR B1*03 and 
      HLA -DR B1*14 alleles showed a tendency statistically significant in Group 1 (9.5 
      percent vs 1.4 percent, p=0.057 and 11.9 percent vs 2.7 percent, p=0.058, 
      respectively). HLA -B*18 and HLA -Cw*07 alleles may probably be associated with 
      susceptibility to venom allergy, whereas HLA -A*03, HLA -Cw*03 and HLA -DQB1*03 
      seem to be protective markers in a small Turkish population.
FAU - Karakis, Gulden Pasaoglu
AU  - Karakis GP
AD  - Ankara University, School of Medicine, Department of Allergic Diseases, Ankara, 
      Turkey. guldenpasaoglu@yahoo.com
FAU - Sin, Betul
AU  - Sin B
FAU - Tutkak, Huseyin
AU  - Tutkak H
FAU - Kose, Kenan
AU  - Kose K
FAU - Misirligil, Zeynep
AU  - Misirligil Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Ann Agric Environ Med
JT  - Annals of agricultural and environmental medicine : AAEM
JID - 9500166
RN  - 0 (Bee Venoms)
RN  - 0 (Wasp Venoms)
SB  - IM
MH  - Adult
MH  - Bee Venoms/*immunology
MH  - Bites and Stings
MH  - Case-Control Studies
MH  - Gene Expression Regulation
MH  - Genes, MHC Class I/*genetics
MH  - Genes, MHC Class II/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypersensitivity/*genetics
MH  - Middle Aged
MH  - Wasp Venoms/*immunology
MH  - Young Adult
EDAT- 2010/08/06 06:00
MHDA- 2011/02/16 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/02/16 06:00 [medline]
AID - 17119 [pii]
PST - ppublish
SO  - Ann Agric Environ Med. 2010;17(1):119-23.