PMID- 20685009
OWN - NLM
STAT- MEDLINE
DCOM- 20120615
LR  - 20211020
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Apr
TI  - Association of serotonin and dopamine gene pathways with behavioral subphenotypes 
      in dementia.
PG  - 791-803
LID - 10.1016/j.neurobiolaging.2010.06.011 [doi]
AB  - Genetic association studies investigating the association between genes of 
      serotonergic and dopaminergic systems and behavioral and psychological symptoms 
      in dementia (BPSD) are contradictory. We have utilized 1008 probable Alzheimer's 
      disease (AD) patients from the UK and used the 12-item Neuropsychiatric 
      Inventory. We applied a multiple indicators-multiple causes (MIMIC) approach to 
      investigate the effect of 11 polymorphisms on the 4 behavioral subphenotypes 
      "psychosis", "moods", "agitation", and "behavioural dyscontrol". Significant 
      associations were observed between the serotonin transporter gene (SERT) 
      polymorphism STin2 and "psychosis"; the dopamine transporter gene (DAT) 3' 
      variable number tandem repeats (VNTR) and "agitation"; and the dopamine receptor 
      4 (DRD4) VNTR and "moods" factors. Direct associations were identified between 
      the dopamine receptor 3 (DRD3) BalI polymorphism and depression; the dopamine 
      receptor 1 (DRD1) and dopamine transporter gene 3' VNTR polymorphisms and 
      aberrant motor behavior; the DRD4 VNTR and sleep disturbances; and the SERT gene 
      VNTR 5HTTLPR and apathy items. Significant interactions observed between 
      polymorphisms suggested epistatic effects and interactions between polymorphisms 
      and medications highlighted potential treatment response. This multiple 
      indicators multiple causes (MIMIC) model efficiently captured the complexity of 
      the interrelations between genetic variation, behavioral symptoms, and clinical 
      variables.
CI  - Copyright A(c) 2012 Elsevier Inc. All rights reserved.
FAU - Proitsi, Petroula
AU  - Proitsi P
AD  - Institute of Psychiatry, King's College London, London, UK. 
      petroula.proitsi@kcl.ac.uk
FAU - Lupton, Michelle K
AU  - Lupton MK
FAU - Reeves, Suzanne J
AU  - Reeves SJ
FAU - Hamilton, Gillian
AU  - Hamilton G
FAU - Archer, Nicola
AU  - Archer N
FAU - Martin, Belinda M
AU  - Martin BM
FAU - Iyegbe, Conrad
AU  - Iyegbe C
FAU - Hollingworth, Paul
AU  - Hollingworth P
FAU - Lawlor, Brian
AU  - Lawlor B
FAU - Gill, Michael
AU  - Gill M
FAU - Brayne, Carol
AU  - Brayne C
FAU - Rubinsztein, David C
AU  - Rubinsztein DC
FAU - Owen, Michael J
AU  - Owen MJ
FAU - Williams, Julie
AU  - Williams J
FAU - Lovestone, Simon
AU  - Lovestone S
FAU - Powell, John F
AU  - Powell JF
LA  - eng
GR  - G0300429/MRC_/Medical Research Council/United Kingdom
GR  - G0902227/MRC_/Medical Research Council/United Kingdom
GR  - G9901400/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100803
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 1.4.3.4 (Monoamine Oxidase)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Apolipoprotein E4/genetics
MH  - Behavioral Symptoms/etiology/*genetics
MH  - Catechol O-Methyltransferase/genetics
MH  - Chi-Square Distribution
MH  - Cohort Studies
MH  - DNA Mutational Analysis
MH  - *Dementia/complications/genetics/psychology
MH  - Dopamine/*genetics
MH  - Dopamine Plasma Membrane Transport Proteins
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minisatellite Repeats/genetics
MH  - Models, Biological
MH  - Monoamine Oxidase/genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Receptors, Dopamine
MH  - Risk Factors
MH  - Serotonin/*genetics
MH  - Serotonin Plasma Membrane Transport Proteins
MH  - Signal Transduction/*genetics
MH  - United Kingdom
EDAT- 2010/08/06 06:00
MHDA- 2012/06/16 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/03/09 00:00 [received]
PHST- 2010/06/10 00:00 [revised]
PHST- 2010/06/16 00:00 [accepted]
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2012/06/16 06:00 [medline]
AID - S0197-4580(10)00276-9 [pii]
AID - 10.1016/j.neurobiolaging.2010.06.011 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2012 Apr;33(4):791-803. doi: 
      10.1016/j.neurobiolaging.2010.06.011. Epub 2010 Aug 3.