PMID- 20685250
OWN - NLM
STAT- MEDLINE
DCOM- 20101229
LR  - 20131121
IS  - 1879-3649 (Electronic)
IS  - 1537-1891 (Linking)
VI  - 53
IP  - 3-4
DP  - 2010 Sep-Oct
TI  - Hydrogen sulfide: regulatory role on blood pressure in hyperhomocysteinemia.
PG  - 138-43
LID - 10.1016/j.vph.2010.05.004 [doi]
AB  - Hyperhomocysteinemia (HHcy) is a metabolic disorder marked by an excess amount of 
      the amino acid homocysteine (Hcy) in the blood stream. Hcy is a H(2)S 
      precursor-formed from the metabolism of methionine. Elevated Hcy levels have been 
      associated with higher blood pressure. However, the precise contribution of H(2)S 
      to blood pressure in HHcy is not known. In the current study, we have examined a 
      novel link between H(2)S, blood pressure and HHcy. Male Sprague-Dawley rats were 
      injected with PAG, NaHS, L-NAME+PAG and saline. HHcy condition was induced by 
      providing methionine (1 g/kg) in drinking water for 8 weeks. After 8 weeks, 
      plasma Hcy and H(2)S were measured. The treated rats were anaesthetized with a 
      mixture of ketamine hydrochloride and medetomidine. Blood pressures were measured 
      by intra-carotid artery catheterization and to further investigate the immediate 
      effect of NO and H(2)S, exogenous drugs namely NaHS, SNP, Ach and NA were 
      administered. Plasma Hcy levels were higher in HHcy groups and this group 
      exhibited hypertension. We observed high blood pressure at low levels of H(2)S 
      and vice versa. Endogenous H(2)S in HHcy condition facilitated a mild decrease in 
      MAP (Mean Arterial Pressure). Exogenous SNP (NO donor) showed a greater pressure 
      decrease in HHcy group. The underlying mechanism is yet to be exploited. High 
      levels of Hcy play an important role in the pathogenesis of hypertension. The 
      results suggest that both endogenous and exogenous H(2)S may play a vital role in 
      regulating blood pressure in HHcy.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Sowmya, Sagiraju
AU  - Sowmya S
AD  - Department of Pharmacology, National University of Singapore, Singapore, 
      Singapore.
FAU - Swathi, Yada
AU  - Swathi Y
FAU - Yeo, Ai Ling
AU  - Yeo AL
FAU - Shoon, Mei Leng
AU  - Shoon ML
FAU - Moore, Philip Keith
AU  - Moore PK
FAU - Bhatia, Madhav
AU  - Bhatia M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100601
PL  - United States
TA  - Vascul Pharmacol
JT  - Vascular pharmacology
JID - 101130615
RN  - 0 (Sulfides)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 169D1260KM (Nitroprusside)
RN  - AE28F7PNPL (Methionine)
RN  - FWU2KQ177W (sodium bisulfide)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
RN  - YY9FVM7NSN (Hydrogen Sulfide)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Homocysteine/blood/pharmacology
MH  - Hydrogen Sulfide/*blood/pharmacology
MH  - Hyperhomocysteinemia/*metabolism/*physiopathology
MH  - Male
MH  - Methionine/pharmacology
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitroprusside/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sulfides/pharmacology
EDAT- 2010/08/06 06:00
MHDA- 2010/12/30 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/03/04 00:00 [received]
PHST- 2010/05/16 00:00 [revised]
PHST- 2010/05/23 00:00 [accepted]
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/12/30 06:00 [medline]
AID - S1537-1891(10)00103-5 [pii]
AID - 10.1016/j.vph.2010.05.004 [doi]
PST - ppublish
SO  - Vascul Pharmacol. 2010 Sep-Oct;53(3-4):138-43. doi: 10.1016/j.vph.2010.05.004. 
      Epub 2010 Jun 1.