PMID- 20685687
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20171116
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 10
DP  - 2010 Oct
TI  - Soluble receptor of advanced glycation end products levels are related to 
      ischaemic aetiology and extent of coronary disease in chronic heart failure 
      patients, independent of advanced glycation end products levels: New Roles for 
      Soluble RAGE.
PG  - 1092-100
LID - 10.1093/eurjhf/hfq117 [doi]
AB  - AIMS: Knowledge of the role of advanced glycation end products (AGE), their 
      receptor (RAGE), and the receptor's soluble form (sRAGE), in heart failure (HF) 
      is very limited. We evaluated the clinical role of the AGE-RAGE system in HF and 
      in particular any association it might have with ischaemic aetiology. METHODS AND 
      RESULTS: We measured fluorescent AGE, glycated albumin and sRAGE in 103 patients 
      with chronic HF. We showed that sRAGE but not AGE was related to ischaemic 
      aetiology (1638.3 +/- 207.4 ischaemic vs. 1065.1 +/- 94.2 pg/mL non-ischaemic group; 
      P =0.016) independent of age, sex, diabetes, renal function, clinical severity, 
      or other variables (OR: 1.091; 95% CI (confidence interval): 1.032-1.153; P 
      =0.007). Moreover, sRAGE was directly associated with extent of coronary disease 
      (OR for three vessel disease compared with non-coronary lesions: 1.186; 95% CI: 
      1.065-1.322; P =0.002). We also found a correlation between sRAGE and severity of 
      HF, which increased with New York Heart Association (NYHA) class (741.9 +/- 88.9 
      pg/mL in class 1, 1195.9 +/- 113.2 pg/mL in class II, and 1724.8 +/- 245.7 pg/mL in 
      class III (P < 0.05)) and brain natriuretic peptide (BNP) levels (667.4 +/- 68.0 
      vs. 1344.5 +/- 126.0 pg/mL for BNP < and >/=400 pg/mL, respectively). CONCLUSION: 
      sRAGE is an indicator of chronic heart failure severity and an independent marker 
      of coronary artery disease and its severity in patients with CHF.
FAU - Raposeiras-Roubin, Sergio
AU  - Raposeiras-Roubin S
AD  - Cardiology Department and Coronary Unit, Clinical Hospital of Santiago de 
      Compostela, Santiago, Spain.
FAU - Rodino-Janeiro, Bruno K
AU  - Rodino-Janeiro BK
FAU - Grigorian-Shamagian, Lilian
AU  - Grigorian-Shamagian L
FAU - Moure-Gonzalez, Maria
AU  - Moure-Gonzalez M
FAU - Seoane-Blanco, Ana
AU  - Seoane-Blanco A
FAU - Varela-Roman, Alfonso
AU  - Varela-Roman A
FAU - Alvarez, Ezequiel
AU  - Alvarez E
FAU - Gonzalez-Juanatey, Jose R
AU  - Gonzalez-Juanatey JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100803
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Albumins)
RN  - 0 (Glycation End Products, Advanced)
SB  - IM
MH  - Aged
MH  - Albumins
MH  - Chronic Disease
MH  - Confidence Intervals
MH  - Coronary Artery Disease/blood/metabolism/*pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Glycation End Products, Advanced/*blood
MH  - Heart Failure/blood/metabolism/*pathology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Statistics as Topic
EDAT- 2010/08/06 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - hfq117 [pii]
AID - 10.1093/eurjhf/hfq117 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Oct;12(10):1092-100. doi: 10.1093/eurjhf/hfq117. Epub 2010 
      Aug 3.