PMID- 20686339
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20190911
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 35
IP  - 4
DP  - 2010 Aug
TI  - Effects of perfluorooctanoic acid (PFOA) exposure to pregnant mice on 
      reproduction.
PG  - 527-33
AB  - Perfluorooctanoic acid (PFOA) has similar characteristics to perfluorooctane 
      sulfonate (PFOS) in reproduction toxicity featured by neonatal death. We found 
      that PFOS exposure to mice during pregnancy led to intracranial blood vessel 
      dilatation of fetuses accompanied by severe lung collapse which caused neonatal 
      mortality. Thus, we adopted the corresponding experimental design to PFOS in 
      order to characterize the neonatal death by PFOA. Pregnant ICR mice were given 1, 
      5 and 10 mg/kg PFOA daily by gavage from gestational day (GD) 0 to 17 and 18 for 
      prenatal and postnatal evaluations, respectively. Five to nine dams per group 
      were sacrificed on GD 18 for prenatal evaluation; other 10 dams were left to give 
      birth. No maternal death was observed. The liver weight increased 
      dose-dependently, with hepatocellular hypertrophy, necrosis, increased mitosis 
      and mild calcification at 10 mg/kg. PFOA at 10 mg/kg increased serum enzyme 
      activities (GGT, ALT, AST and ALP) with hypoproteinemia and hypolipidemia. PFOA 
      treatment reduced the fetal body weight at 5 and 10 mg/kg. Teratological 
      evaluation showed delayed ossification of the sternum and phalanges and delayed 
      eruption of incisors at 10 mg/kg, but did not show intracranial blood vessel 
      dilatation. Postnatal evaluation revealed that PFOA reduced the neonatal survival 
      rate at 5 and 10 mg/kg. At 5 mg/kg pups were born alive and active and 16% died 
      within 4 days observation, while all died within 6 hr after birth at 10 mg/kg 
      without showing intracranial blood vessel dilatation. The cause of neonatal death 
      by PFOA may be different from PFOS.
FAU - Yahia, Doha
AU  - Yahia D
AD  - Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, 
      Assiut University, Assiut, Egypt.
FAU - El-Nasser, Mahmoud Abd
AU  - El-Nasser MA
FAU - Abedel-Latif, Manal
AU  - Abedel-Latif M
FAU - Tsukuba, Chiaki
AU  - Tsukuba C
FAU - Yoshida, Midori
AU  - Yoshida M
FAU - Sato, Itaru
AU  - Sato I
FAU - Tsuda, Shuji
AU  - Tsuda S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Caprylates)
RN  - 0 (Fluorocarbons)
RN  - 947VD76D3L (perfluorooctanoic acid)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Caprylates/*toxicity
MH  - Female
MH  - Fetus/drug effects
MH  - Fluorocarbons/*toxicity
MH  - Gravidity/drug effects
MH  - Liver/drug effects
MH  - Maternal Exposure/*adverse effects
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Reproduction/drug effects
EDAT- 2010/08/06 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - JST.JSTAGE/jts/35.527 [pii]
AID - 10.2131/jts.35.527 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2010 Aug;35(4):527-33. doi: 10.2131/jts.35.527.