PMID- 20686867
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20211020
IS  - 1558-9307 (Electronic)
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 45
IP  - 8
DP  - 2010 Aug
TI  - Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL 
      receptor null mice fed an atherogenic diet.
PG  - 701-11
LID - 10.1007/s11745-010-3454-8 [doi]
AB  - The effect of an atherogenic diet on inflammatory response and elicited 
      peritoneal macrophage (Mphi) cholesterol accumulation in relation to aortic 
      lesion formation was assessed in LDL receptor null (LDLr-/-) mice. Mice were fed 
      an atherogenic or control diet for 32 weeks. The atherogenic relative to control 
      diet resulted in significantly higher plasma monocyte chemoattractant protein-1 
      (MCP-1), tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) 
      concentrations, more aortic wall Mphi deposition, higher serum non 
      HDL-cholesterol concentrations and total cholesterol to HDL-cholesterol ratios, 
      and greater accumulation of both aortic free and esterified cholesterol. Elicited 
      peritoneal Mphi selectively accumulated longer chain unsaturated fatty acids in 
      their membrane, independent of the dietary fatty acid profile. Elicited 
      peritoneal Mphi isolated from mice fed the atherogenic relative to control diet 
      had significantly less arachidonic acid levels, accumulated significantly higher 
      esterified cholesterol, had significantly higher mRNA levels and secretion of 
      MCP-1, and mRNA and protein levels of ATP-binding cassette A1. Diet treatment had 
      no significant effect in elicited peritoneal Mphi on TNFalpha and IL-6 mRNA 
      levels and secretion. These data suggest that the atherogenic relative to control 
      diet resulted in higher plasma inflammatory factor concentrations, less favorable 
      lipoprotein profile, higher elicited peritoneal Mphi cholesterol accumulation and 
      inflammatory factor secretion, and more aortic wall Mphi deposition, which in 
      turn were associated with greater aortic cholesterol accumulation.
FAU - Wang, Shu
AU  - Wang S
AD  - Cardiovascular Nutrition Laboratory, JM USDA Human Nutrition Research Center on 
      Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.
FAU - Wu, Dayong
AU  - Wu D
FAU - Matthan, Nirupa R
AU  - Matthan NR
FAU - Lamon-Fava, Stefania
AU  - Lamon-Fava S
FAU - Lecker, Jaime L
AU  - Lecker JL
FAU - Lichtenstein, Alice H
AU  - Lichtenstein AH
LA  - eng
GR  - R01 HL 54727/HL/NHLBI NIH HHS/United States
GR  - R01 HL054727-03/HL/NHLBI NIH HHS/United States
GR  - T32 HL069772-01A1/HL/NHLBI NIH HHS/United States
GR  - R01 HL054727-04/HL/NHLBI NIH HHS/United States
GR  - R01 HL054727-06/HL/NHLBI NIH HHS/United States
GR  - R01 HL054727-05/HL/NHLBI NIH HHS/United States
GR  - R01 HL054727/HL/NHLBI NIH HHS/United States
GR  - R01 HL054727-07/HL/NHLBI NIH HHS/United States
GR  - T32 HL69772-01A1/HL/NHLBI NIH HHS/United States
GR  - T32 HL069772/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100805
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Lipids)
RN  - 0 (Receptors, LDL)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/chemically induced/immunology/metabolism
MH  - Body Weight/drug effects/genetics
MH  - *Diet, Atherogenic
MH  - Eating/drug effects/genetics
MH  - Lipid Metabolism/*drug effects
MH  - Lipids/blood
MH  - Macrophages/drug effects/*immunology/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, LDL/*deficiency/genetics
PMC - PMC2935317
MID - NIHMS231280
COIS- Conflict of interest All authors have no conflict of interest.
EDAT- 2010/08/06 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/08/05
CRDT- 2010/08/06 06:00
PHST- 2010/03/15 00:00 [received]
PHST- 2010/07/08 00:00 [accepted]
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/08/05 00:00 [pmc-release]
AID - 10.1007/s11745-010-3454-8 [doi]
PST - ppublish
SO  - Lipids. 2010 Aug;45(8):701-11. doi: 10.1007/s11745-010-3454-8. Epub 2010 Aug 5.