PMID- 2068787 OWN - NLM STAT- MEDLINE DCOM- 19910812 LR - 20190912 IS - 0168-9525 (Print) IS - 0168-9525 (Linking) VI - 7 IP - 5 DP - 1991 May TI - Fluorescence in situ hybridization: applications in cytogenetics and gene mapping. PG - 149-54 AB - Unique sequences, chromosomal subregions, or entire genomes can be specifically highlighted in metaphase or interphase cells by fluorescence in situ hybridization (FISH). This technique can be used to identify chromosomes, detect chromosomal abnormalities or determine the chromosomal location of specific sequences. FISH plays an increasingly important role in a variety of research areas, including cytogenetics, prenatal diagnosis, tumor biology, gene amplification and gene mapping. FAU - Trask, B J AU - Trask BJ AD - Biomedical Sciences Division, Lawrence Livermore National Laboratory, Livermore, CA 94550. LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Review PL - England TA - Trends Genet JT - Trends in genetics : TIG JID - 8507085 SB - IM MH - Animals MH - Chromosome Mapping MH - Fluorescence MH - Genetic Techniques MH - Humans MH - *Nucleic Acid Hybridization RF - 43 EDAT- 1991/05/01 00:00 MHDA- 1991/05/01 00:01 CRDT- 1991/05/01 00:00 PHST- 1991/05/01 00:00 [pubmed] PHST- 1991/05/01 00:01 [medline] PHST- 1991/05/01 00:00 [entrez] AID - 0168-9525(91)90378-4 [pii] AID - 10.1016/0168-9525(91)90378-4 [doi] PST - ppublish SO - Trends Genet. 1991 May;7(5):149-54. doi: 10.1016/0168-9525(91)90378-4.