PMID- 20688156
OWN - NLM
STAT- MEDLINE
DCOM- 20110415
LR  - 20181201
IS  - 1873-3913 (Electronic)
IS  - 0898-6568 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Feb
TI  - Pannexin channels in ATP release and beyond: an unexpected rendezvous at the 
      endoplasmic reticulum.
PG  - 305-16
LID - 10.1016/j.cellsig.2010.07.018 [doi]
AB  - The pannexin (Panx) family of proteins, which is co-expressed with connexins 
      (Cxs) in vertebrates, was found to be a new GJ-forming protein family related to 
      invertebrate innexins. During the past ten years, different studies showed that 
      Panxs mainly form hemichannels in the plasma membrane and mediate paracrine 
      signalling by providing a flux pathway for ions such as Ca(2)(+), for ATP and 
      perhaps for other compounds, in response to physiological and pathological 
      stimuli. Although the physiological role of Panxs as a hemichannel was 
      questioned, there is increasing evidence that Panx play a role in vasodilatation, 
      initiation of inflammatory responses, ischemic death of neurons, epilepsy and in 
      tumor suppression. Moreover, it is intriguing that Panxs may also function at the 
      endoplasmic reticulum (ER) as intracellular Ca(2)(+)-leak channel and may be 
      involved in ER-related functions. Although the physiological significance and 
      meaning of such Panx-regulated intracellular Ca(2)(+) leak requires further 
      exploration, this functional property places Panx at the centre of many 
      physiological and pathophysiological processes, given the fundamental role of 
      intracellular Ca(2)(+) homeostasis and dynamics in a plethora of physiological 
      processes. In this review, we therefore want to focus on Panx as channels at the 
      plasma membrane and at the ER membranes with a particular emphasis on the 
      potential implications of the latter in intracellular Ca(2)(+) signalling.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - D'hondt, Catheleyne
AU  - D'hondt C
AD  - Laboratory of Molecular and Cellular Signalling, K.U. Leuven, Campus Gasthuisberg 
      O/N-1 bus 802, B-3000 Leuven, Belgium.
FAU - Ponsaerts, Raf
AU  - Ponsaerts R
FAU - De Smedt, Humbert
AU  - De Smedt H
FAU - Vinken, Mathieu
AU  - Vinken M
FAU - De Vuyst, Elke
AU  - De Vuyst E
FAU - De Bock, Marijke
AU  - De Bock M
FAU - Wang, Nan
AU  - Wang N
FAU - Rogiers, Vera
AU  - Rogiers V
FAU - Leybaert, Luc
AU  - Leybaert L
FAU - Himpens, Bernard
AU  - Himpens B
FAU - Bultynck, Geert
AU  - Bultynck G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (Connexins)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/*metabolism
MH  - Animals
MH  - Calcium Signaling/physiology
MH  - Cell Membrane/metabolism
MH  - Connexins/*physiology
MH  - Endoplasmic Reticulum/*metabolism
MH  - Humans
MH  - Mice
EDAT- 2010/08/07 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/08/07 06:00
PHST- 2010/06/29 00:00 [received]
PHST- 2010/07/22 00:00 [accepted]
PHST- 2010/08/07 06:00 [entrez]
PHST- 2010/08/07 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - S0898-6568(10)00211-1 [pii]
AID - 10.1016/j.cellsig.2010.07.018 [doi]
PST - ppublish
SO  - Cell Signal. 2011 Feb;23(2):305-16. doi: 10.1016/j.cellsig.2010.07.018. Epub 2010 
      Aug 3.