PMID- 20691687
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20100927
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 584
IP  - 18
DP  - 2010 Sep 24
TI  - Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I.
PG  - 3979-84
LID - 10.1016/j.febslet.2010.07.059 [doi]
AB  - We analysed the function and intracellular signalling of the cyclic pyrimidinic 
      nucleotide cCMP. The membrane-permeable cCMP analogue dibutyryl-cCMP mediated 
      mouse aorta relaxation. cCMP activated purified cGMP-dependent protein kinase 
      (cGK) Ialpha and Ibeta and stimulated cGK in aorta lysates. cCMP-induced relaxation was 
      abolished in cGKI-knockout tissue. Additionally, deletion of 
      inositol-trisphosphate receptor associated cGKI substrate (IRAG) suppressed 
      cCMP-mediated relaxation. Signalling of cCMP via cGKI/IRAG appears to be of 
      broader physiological importance because cCMP-mediated inhibition of platelet 
      aggregation was absent in cGKI- and IRAG-deficient platelets. These results 
      demonstrate that cCMP acts as intracellular messenger molecule, most unexpectedly 
      utilizing the cGMP signal transduction pathway.
CI  - Copyright (c) 2010 Federation of European Biochemical Societies. Published by 
      Elsevier B.V. All rights reserved.
FAU - Desch, Matthias
AU  - Desch M
AD  - Pharmacology and Toxicology, University Regensburg, Regensburg, Germany.
FAU - Schinner, Elisabeth
AU  - Schinner E
FAU - Kees, Frieder
AU  - Kees F
FAU - Hofmann, Franz
AU  - Hofmann F
FAU - Seifert, Roland
AU  - Seifert R
FAU - Schlossmann, Jens
AU  - Schlossmann J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100806
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Inositol 1,4,5-Trisphosphate Receptors)
RN  - 3616-08-8 (Cyclic CMP)
RN  - EC 2.7.11.12 (Cyclic GMP-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Aorta/drug effects/enzymology/physiology
MH  - Cyclic CMP/*metabolism/pharmacology
MH  - Cyclic GMP-Dependent Protein Kinases/genetics/*metabolism
MH  - Inositol 1,4,5-Trisphosphate Receptors/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - *Muscle Relaxation
MH  - Muscle, Smooth/drug effects/enzymology/*physiology
MH  - Platelet Aggregation/drug effects/physiology
MH  - Signal Transduction
EDAT- 2010/08/10 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/05/11 00:00 [received]
PHST- 2010/07/13 00:00 [revised]
PHST- 2010/07/29 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - S0014-5793(10)00627-7 [pii]
AID - 10.1016/j.febslet.2010.07.059 [doi]
PST - ppublish
SO  - FEBS Lett. 2010 Sep 24;584(18):3979-84. doi: 10.1016/j.febslet.2010.07.059. Epub 
      2010 Aug 6.