PMID- 20691797
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20221207
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 18
IP  - 11
DP  - 2010 Nov
TI  - Association of single-nucleotide polymorphisms in HLA class II/III region with 
      knee osteoarthritis.
PG  - 1454-7
LID - 10.1016/j.joca.2010.07.009 [doi]
AB  - OBJECTIVE: A genome-wide association study and a replication using Japanese, 
      Spanish and Greek Caucasian populations have recently indicated two 
      single-nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with 
      knee Osteoarthritis (OA) susceptibility. We have further evaluated the 
      association in knee OA subjects from Han Chinese and Australian Caucasian origin. 
      METHODS: Two independent case-control association studies were performed using 
      Han Chinese and Australian Caucasian populations. The two SNPs were genotyped in 
      patients who had primary symptomatic knee OA with radiographic confirmation 
      and/or received total knee replacement surgery as well as in matched controls. 
      They were subjected to statistic analyses. RESULTS: A total of 991 OA patients 
      and 1536 controls were genotyped. No significant difference was detected in 
      genotype or allele frequencies of the two SNPs between knee OA and control groups 
      in the two populations (all P>0.05). The association was also negative even after 
      stratification by sex, body mass index (BMI) and Kellgren/Lawrence scores. The 
      significant heterogeneity was detected between Chinese and Japanese (both 
      P<0.05). In the Caucasian samples, no significant heterogeneity was detected 
      (both P>0.05). The result of meta-analysis showed significant association between 
      knee OA and rs10947262 in total subjects [summary OR=1.26, 95%confidence 
      intervals (CI)=1.07-1.27, P=3 x 10(-8)] and in Caucasian samples (summary 
      OR=1.28, 95%CI=1.04-1.57, P=0.02). CONCLUSION: We demonstrated no association 
      between the two SNPs in human leukocyte antigen (HLA) class II/III region and 
      knee OA in Han Chinese population. A significant association was detected between 
      SNP rs10947262 and knee OA in Caucasian subjects. Further replication studies are 
      required to identify the impact of controversial association.
CI  - Copyright (c) 2010 Osteoarthritis Research Society International. All rights 
      reserved.
FAU - Shi, D
AU  - Shi D
AD  - The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital 
      Affiliated to Medical School of Nanjing University, Nanjing 210008, Jiangsu, 
      China.
FAU - Zheng, Q
AU  - Zheng Q
FAU - Chen, D
AU  - Chen D
FAU - Zhu, L
AU  - Zhu L
FAU - Qin, A
AU  - Qin A
FAU - Fan, J
AU  - Fan J
FAU - Liao, J
AU  - Liao J
FAU - Xu, Z
AU  - Xu Z
FAU - Lin, Z
AU  - Lin Z
FAU - Norman, P
AU  - Norman P
FAU - Xu, J
AU  - Xu J
FAU - Nakamura, T
AU  - Nakamura T
FAU - Dai, K
AU  - Dai K
FAU - Zheng, M
AU  - Zheng M
FAU - Jiang, Q
AU  - Jiang Q
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20100805
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Asian People/genetics
MH  - Australia
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Osteoarthritis, Knee/diagnostic imaging/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Radiography
MH  - White People/genetics
EDAT- 2010/08/10 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/04/08 00:00 [received]
PHST- 2010/07/18 00:00 [revised]
PHST- 2010/07/20 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S1063-4584(10)00245-1 [pii]
AID - 10.1016/j.joca.2010.07.009 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2010 Nov;18(11):1454-7. doi: 
      10.1016/j.joca.2010.07.009. Epub 2010 Aug 5.