PMID- 20692125
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20240322
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 123
IP  - 2-3
DP  - 2010 Nov
TI  - Neuropsychological profiles in individuals at clinical high risk for psychosis: 
      relationship to psychosis and intelligence.
PG  - 188-98
LID - 10.1016/j.schres.2010.06.021 [doi]
AB  - BACKGROUND: Characterizing neuropsychological (NP) functioning of individuals at 
      clinical high risk (CHR) for psychosis may be useful for prediction of psychosis 
      and understanding functional outcome. The degree to which NP impairments are 
      associated with general cognitive ability and/or later emergence of full 
      psychosis in CHR samples requires study with well-matched controls. METHODS: We 
      assessed NP functioning across eight cognitive domains in a sample of 73 CHR 
      youth, 13 of whom developed psychotic-level symptoms after baseline assessment, 
      and 34 healthy comparison (HC) subjects. Groups were matched on age, sex, 
      ethnicity, handedness, subject and parent grade attainment, and median family 
      income, and were comparable on WRAT-3 Reading, an estimate of premorbid IQ. 
      Profile analysis was used to examine group differences and the role of IQ in 
      profile shape. RESULTS: The CHR sample demonstrated a significant difference in 
      overall magnitude of NP impairment but only a small and nearly significant 
      difference in profile shape, primarily due to a large impairment in olfactory 
      identification. Individuals who subsequently developed psychotic-level symptoms 
      demonstrated large impairments in verbal IQ, verbal memory and olfactory 
      identification comparable in magnitude to first episode samples. CONCLUSIONS: CHR 
      status may be associated with moderate generalized cognitive impairments marked 
      by some degree of selective impairment in olfaction and verbal memory. 
      Impairments were greatest in those who later developed psychotic symptoms. Future 
      study of olfaction in CHR samples may enhance early detection and specification 
      of neurodevelopmental mechanisms of risk.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Woodberry, Kristen A
AU  - Woodberry KA
AD  - Center for Psychiatric Research, Maine Medical Center, 295 Park Avenue, Portland, 
      ME 04102, USA. kwoodber@bidmc.harvard.edu
FAU - Seidman, Larry J
AU  - Seidman LJ
FAU - Giuliano, Anthony J
AU  - Giuliano AJ
FAU - Verdi, Mary B
AU  - Verdi MB
FAU - Cook, William L
AU  - Cook WL
FAU - McFarlane, William R
AU  - McFarlane WR
LA  - eng
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01 MH065367/MH/NIMH NIH HHS/United States
GR  - P50 MH080272-02/MH/NIMH NIH HHS/United States
GR  - R01MH065367/MH/NIMH NIH HHS/United States
GR  - 1 U01 MH081928-01A1/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100809
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - *Cognition
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - *Intelligence
MH  - Intelligence Tests
MH  - Male
MH  - *Memory
MH  - Neuropsychological Tests
MH  - *Olfactory Perception
MH  - Psychotic Disorders/*diagnosis/psychology
MH  - Risk Assessment
MH  - Sensory Thresholds
MH  - *Verbal Learning
MH  - Young Adult
PMC - PMC2964352
MID - NIHMS230221
EDAT- 2010/08/10 06:00
MHDA- 2011/02/22 06:00
PMCR- 2011/11/01
CRDT- 2010/08/10 06:00
PHST- 2010/02/19 00:00 [received]
PHST- 2010/06/27 00:00 [revised]
PHST- 2010/06/29 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - S0920-9964(10)01378-2 [pii]
AID - 10.1016/j.schres.2010.06.021 [doi]
PST - ppublish
SO  - Schizophr Res. 2010 Nov;123(2-3):188-98. doi: 10.1016/j.schres.2010.06.021. Epub 
      2010 Aug 9.