PMID- 20692245
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20100920
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 43
IP  - 15
DP  - 2010 Oct
TI  - Insertion/insertion genotype of alpha(2B)-adrenergic receptor gene polymorphism is 
      associated with silent myocardial ischemia in patients with type 2 diabetes 
      mellitus.
PG  - 1201-4
LID - 10.1016/j.clinbiochem.2010.07.023 [doi]
AB  - OBJECTIVES: We investigated whether alpha(2)-adrenergic receptor (AR) polymorphisms 
      (alpha(2A)-AR, alpha(2B)-AR and alpha(2C)-AR gene) affected silent myocardial ischemia (SMI) 
      in patients with type 2 diabetes mellitus (T2DM). DESIGN AND METHODS: Genetic 
      polymorphisms were determined in 321 patients with T2DM and coronary artery 
      disease (CAD). Among them, 129 patients experienced transient asymptomatic 
      ST-depression during 24-hour ambulatory electrocardiogram (SMI group), and the 
      remaining 192 patients who had ambulatory electrocardiogram-symptom matching 
      angina were categorized as angina group. RESULTS: The genotype distribution and 
      allele frequencies of alpha(2B)-AR gene polymorphism (insertion [I]/deletion[D]) 
      exhibited significant difference between SMI group and angina group (both P < 
      0.05), with genotype II (34.9%) being higher in SMI group than in angina group 
      (19.8%) (P < 0.01). Multivariable logistic regression analysis revealed that 
      duration of diabetes and genotype II of alpha(2B)-AR gene polymorphism were 
      independently associated with SMI. CONCLUSIONS: Homozygote for I allele of 
      alpha(2B)-AR gene polymorphism is associated with SMI in T2DM patients with CAD.
CI  - Copyright (c) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - Chen, Qiu Jing
AU  - Chen QJ
AD  - Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School 
      of Medicine, Shanghai 200025, People's Republic of China.
FAU - Lu, Lin
AU  - Lu L
FAU - Jin, Cao
AU  - Jin C
FAU - Wang, Ling Jie
AU  - Wang LJ
FAU - Zhang, Rui Yan
AU  - Zhang RY
FAU - Zhang, Qi
AU  - Zhang Q
FAU - Hu, Jian
AU  - Hu J
FAU - Yang, Zhen Kun
AU  - Yang ZK
FAU - Shen, Wei Feng
AU  - Shen WF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100805
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (ADRA2B protein, human)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Adrenergic, alpha-2)
SB  - IM
MH  - Aged
MH  - Cytokines/blood
MH  - Diabetes Mellitus, Type 2/blood/*complications/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - Mutagenesis, Insertional/*genetics
MH  - Myocardial Ischemia/blood/*complications/*genetics
MH  - Receptors, Adrenergic, alpha-2/*genetics
MH  - Regression Analysis
EDAT- 2010/08/10 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2010/07/21 00:00 [revised]
PHST- 2010/07/22 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - S0009-9120(10)00338-3 [pii]
AID - 10.1016/j.clinbiochem.2010.07.023 [doi]
PST - ppublish
SO  - Clin Biochem. 2010 Oct;43(15):1201-4. doi: 10.1016/j.clinbiochem.2010.07.023. 
      Epub 2010 Aug 5.