PMID- 20692313
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20220317
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 48
IP  - 11
DP  - 2010 Nov
TI  - Polychlorinated biphenyls (PCBs) contamination and aryl hydrocarbon receptor 
      (AhR) agonist activity of Omega-3 polyunsaturated fatty acid supplements: 
      implications for daily intake of dioxins and PCBs.
PG  - 3093-7
LID - 10.1016/j.fct.2010.07.051 [doi]
AB  - Omega-3 polyunsaturated fatty acid (n-3 PUFA) rich oils derived primarily from 
      fish are frequently consumed as supplements. Due to the tendency of persistent 
      organic pollutants (POPs) to accumulate in exposed organisms, n-3 PUFA 
      supplements can contain sufficient POPs to present a risk to consumers. Here we 
      investigated PCB concentrations and aryl hydrocarbon receptor (AhR) agonist 
      activity in 17 n-3 PUFA supplements available in Canada. PCBs ranged from <0.8 to 
      793 ng g(-1) oil, with salmon- and seal-derived products yielding the highest 
      values. AhR agonist activity from a reporter gene assay ranged from 1.3 to 72.2 
      pg TEQ g(-1) oil, with salmon and tuna yielding the highest values. When consumed 
      at the recommended doses and as a supplement to the average Canadian diet, 
      seal-derived oil can contribute to exceedance of the tolerable daily intake of 20 
      ng PCBs kg-BW(-1)day(-1), and salmon-, tuna-, and sea herring-derived oils can 
      contribute to exceedance of the tolerable daily intake limit of 2.3 pg TEQ 
      kg-BW(-1)day(-1). The beneficial properties of fish and n-3 PUFA supplements, and 
      the results of this study suggest that it is prudent to consume supplements 
      derived from small, cold-water fatty fish. Further research will be necessary to 
      draw firm conclusions.
CI  - Crown Copyright (c) 2010. Published by Elsevier Ltd. All rights reserved.
FAU - Bourdon, J A
AU  - Bourdon JA
AD  - Mechanistic Studies Division, Environmental Health Sciences and Research Bureau, 
      Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, 
      Canada. julie_bourdon@hc-sc.gc.ca
FAU - Bazinet, T M
AU  - Bazinet TM
FAU - Arnason, T T
AU  - Arnason TT
FAU - Kimpe, L E
AU  - Kimpe LE
FAU - Blais, J M
AU  - Blais JM
FAU - White, P A
AU  - White PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100806
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (AHR protein, human)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fish Oils)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.13.12.- (Luciferases)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors/*agonists
MH  - Cell Line, Transformed
MH  - Chromatography, Gas
MH  - Chromatography, Gel
MH  - Dietary Supplements/*adverse effects/analysis
MH  - Dioxins/*analysis/toxicity
MH  - Environmental Pollutants/*analysis/toxicity
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Fish Oils/chemistry
MH  - Food Contamination/*analysis
MH  - Hepatocytes/drug effects/enzymology
MH  - Humans
MH  - Luciferases/metabolism
MH  - Maximum Allowable Concentration
MH  - Mice
MH  - Polychlorinated Biphenyls/*analysis/toxicity
MH  - Receptors, Aryl Hydrocarbon/*agonists
EDAT- 2010/08/10 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/02/12 00:00 [received]
PHST- 2010/07/06 00:00 [revised]
PHST- 2010/07/31 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - S0278-6915(10)00511-9 [pii]
AID - 10.1016/j.fct.2010.07.051 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2010 Nov;48(11):3093-7. doi: 10.1016/j.fct.2010.07.051. Epub 
      2010 Aug 6.