PMID- 20692702
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20211020
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 31
IP  - 32
DP  - 2010 Nov
TI  - Functionalised polysiloxanes as injectable, in situ curable accommodating 
      intraocular lenses.
PG  - 8153-63
LID - 10.1016/j.biomaterials.2010.07.065 [doi]
AB  - The aged eye's ability to change focus (accommodation) may be restored by 
      replacing the hardened natural lens with a soft gel. Functionalised polysiloxane 
      macromonomers, designed for application as an injectable, in situ curable 
      accommodating intraocular lens (A-IOL), were prepared via a two-step synthesis. 
      Prepolymers were synthesised via ring opening polymerisation (ROP) of 
      octamethylcyclotetrasiloxane (D(4)) and 2,4,6,8-tetramethylcyclotetrasiloxane 
      (D(4)(H)) in toluene using trifluoromethanesulfonic acid (TfOH) as catalyst. 
      Hexaethyldisiloxane (HEDS) was used as the end group to control the molecular 
      weight of the prepolymers, which were then converted to macromonomers by 
      hydrosilylation of the SiH groups with allyl methacrylate (AM) to introduce 
      polymerisable groups. The resulting macromonomers had an injectable consistency 
      and thus, were able to be injected into and refill the empty lens capsular bag. 
      The macromonomers also contained a low ratio of polymerisable groups so that they 
      may be cured on demand, in situ, under irradiation of blue light, in the presence 
      of a photo-initiator, to form a soft polysiloxane gel (an intraocular lens) in 
      the eye. The pre-cure viscosity and post-cure modulus of the polysiloxanes, which 
      are crucial factors for an injectable, in situ curable A-IOL application, were 
      controlled by adjusting the end group and D(4)(H) concentrations, respectively, 
      in the ROP. The macromonomers were fully cured within 5 min under light 
      irradiation, as shown by the rapid change in modulus monitored by photo-rheology. 
      Ex vivo primate lens stretching experiments on an Ex Vivo Accommodation Simulator 
      (EVAS) showed that the polysiloxane gel refilled lenses achieved over 60% of the 
      accommodation amplitude of the natural lens. An in vivo biocompatibility study in 
      rabbits using the lens refilling (Phaco-Ersatz) procedure demonstrated that the 
      soft gels had good biocompatibility with the ocular tissue. The polysiloxane 
      macromonomers meet the targeted optical and mechanical properties of a young 
      natural crystalline lens and show promise as candidate materials for use as 
      injectable, in situ curable A-IOLs for lens refilling procedures.
CI  - Copyright (c) 2010. Published by Elsevier Ltd.
FAU - Hao, Xiaojuan
AU  - Hao X
AD  - CSIRO Molecular and Health Technologies, Bayview Avenue, Clayton, VIC 3168, 
      Australia. xiaojuan.hao@csiro.au
FAU - Jeffery, Justine L
AU  - Jeffery JL
FAU - Wilkie, John S
AU  - Wilkie JS
FAU - Meijs, Gordon F
AU  - Meijs GF
FAU - Clayton, Anthony B
AU  - Clayton AB
FAU - Watling, Jason D
AU  - Watling JD
FAU - Ho, Arthur
AU  - Ho A
FAU - Fernandez, Viviana
AU  - Fernandez V
FAU - Acosta, Carolina
AU  - Acosta C
FAU - Yamamoto, Hideo
AU  - Yamamoto H
FAU - Aly, Mohamed G M
AU  - Aly MG
FAU - Parel, Jean-Marie
AU  - Parel JM
FAU - Hughes, Timothy C
AU  - Hughes TC
LA  - eng
GR  - P30 EY014801/EY/NEI NIH HHS/United States
GR  - R01 EY014225/EY/NEI NIH HHS/United States
GR  - 2 R01 EY14225/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100807
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Biocompatible Materials)
RN  - 0 (Siloxanes)
SB  - IM
MH  - *Accommodation, Ocular
MH  - Animals
MH  - Biocompatible Materials/*chemistry
MH  - Cornea/ultrastructure
MH  - Injections
MH  - Lens, Crystalline/physiology
MH  - *Lenses, Intraocular
MH  - Macaca fascicularis
MH  - Materials Testing
MH  - Rabbits
MH  - Siloxanes/*chemistry
PMC - PMC2950215
MID - NIHMS228899
EDAT- 2010/08/10 06:00
MHDA- 2011/01/05 06:00
PMCR- 2011/11/01
CRDT- 2010/08/10 06:00
PHST- 2010/06/23 00:00 [received]
PHST- 2010/07/15 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - S0142-9612(10)00908-7 [pii]
AID - 10.1016/j.biomaterials.2010.07.065 [doi]
PST - ppublish
SO  - Biomaterials. 2010 Nov;31(32):8153-63. doi: 10.1016/j.biomaterials.2010.07.065. 
      Epub 2010 Aug 7.