PMID- 20695649
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20100810
IS  - 1939-0084 (Electronic)
IS  - 0735-7044 (Linking)
VI  - 124
IP  - 4
DP  - 2010 Aug
TI  - Operant learning requires NMDA-receptor activation in the anterior cingulate 
      cortex and dorsomedial striatum, but not in the orbitofrontal cortex.
PG  - 500-9
LID - 10.1037/a0020270 [doi]
AB  - Previous research has shown that corticostriatal N-methyl-D-aspartate receptor 
      (NMDAR) activation is necessary for operant learning. NMDAR activation induces 
      plasticity-related intracellular signaling processes leading to gene expression, 
      which are hypothesized to be important steps in codifying the content of 
      learning. Operant learning induces immediate early gene (IEG) expression in key 
      corticostriatal structures, namely the dorsomedial striatum (DMS), the 
      orbitofrontal (OFC), and anterior cingulate cortices (ACC). Both the ACC and OFC 
      send glutamatergic projections to the DMS, which is a crucial site for operant 
      behavior. However, the role of NMDAR activation in these corticostriatal regions 
      in operant learning is unknown. To test this hypothesis, the NMDA antagonist AP-5 
      (1 microg/0.5 microl) or saline was bilaterally microinjected into the ACC, OFC, 
      and DMS of food-deprived rats just prior to operant learning sessions. NMDAR 
      antagonism in the ACC and DMS impaired the acquisition of lever pressing for 
      sucrose pellets but had no effect on lever pressing once learned. NMDAR blockade 
      in OFC did not significantly impair operant learning, suggesting that NMDAR 
      activation in operant learning is site-specific. These data extend our 
      understanding of the role of NMDA receptors in operant learning and behavior 
      throughout an extended corticostriatal network.
CI  - 2010 APA, all rights reserved.
FAU - McKee, Brenda L
AU  - McKee BL
AD  - Department of Psychiatry, University of Wisconsin, Madison, 53705, USA. 
      bmckee@wisc.edu
FAU - Kelley, Ann E
AU  - Kelley AE
FAU - Moser, Hannah R
AU  - Moser HR
FAU - Andrzejewski, Matthew E
AU  - Andrzejewski ME
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Conditioning, Operant/drug effects/*physiology
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Feeding Behavior/drug effects/physiology
MH  - Gyrus Cinguli/drug effects/*metabolism
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Prefrontal Cortex/drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*physiology
MH  - Time Factors
EDAT- 2010/08/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 2010-16138-007 [pii]
AID - 10.1037/a0020270 [doi]
PST - ppublish
SO  - Behav Neurosci. 2010 Aug;124(4):500-9. doi: 10.1037/a0020270.