PMID- 20695946
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20220216
IS  - 1751-7176 (Electronic)
IS  - 1524-6175 (Print)
IS  - 1524-6175 (Linking)
VI  - 12
IP  - 8
DP  - 2010 Aug
TI  - Raised plasma urotensin II in type 2 diabetes patients is associated with the 
      metabolic syndrome phenotype.
PG  - 653-60
LID - 10.1111/j.1751-7176.2010.00336.x [doi]
AB  - Urotensin II (UII) exerts multiple effects on the cardiovascular system, acts as 
      a diabetogenic agent, and may also contribute to the development of the metabolic 
      syndrome (MetS). The aim of this study was to determine circulating UII in 
      patients with type 2 diabetes mellitus (T2DM) and its relationship with MetS. A 
      total of 360 consecutive patients with T2DM were included. MetS presence/absence 
      (MetS [+]/[-]) was defined according to American Heart Association/National 
      Heart, Lung and Blood Institute criteria. Plasma concentrations of UII were 
      determined by radioimmunoassay. UII levels were significantly higher in MetS (+) 
      than in MetS (-) T2DM patients (0.97 pg/mL [0.93-1.01], n=294 vs 0.82 pg/mL 
      [0.75-0.88] pg/mL, n=66, respectively; P<.001). Multiple logistic regression 
      analysis showed that UII was significantly associated with MetS (+) (odds ratio, 
      6.41 [95% confidence interval, 1.21-16.04]; P=.02). UII plasma concentrations are 
      significantly higher in T2DM patients presenting with MetS. Therefore, 
      circulating UII may participate in the worsening course of some T2DM patients and 
      may provide novel therapeutic perspectives.
CI  - (c) 2010 Wiley Periodicals, Inc.
FAU - Gruson, Damien
AU  - Gruson D
AD  - Endocrinology & Nutrition Unit, Universite Catholique de Louvain, Tour Claude 
      Bernard, 54 Avenue Hippocrate, Brussels, Belgium. damien.gruson@uclouvain.be
FAU - Rousseau, Michel F
AU  - Rousseau MF
FAU - Ketelslegers, Jean-Marie
AU  - Ketelslegers JM
FAU - Hermans, Michel P
AU  - Hermans MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Hypertens (Greenwich)
JT  - Journal of clinical hypertension (Greenwich, Conn.)
JID - 100888554
RN  - 0 (Biomarkers)
RN  - 0 (N-terminal proatrial natriuretic peptide)
RN  - 0 (Protein Precursors)
RN  - 0 (Urotensins)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - 9047-55-6 (urotensin II)
SB  - IM
MH  - Aged
MH  - Atrial Natriuretic Factor/blood
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Metabolic Syndrome/*blood
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - *Phenotype
MH  - Protein Precursors/blood
MH  - Retrospective Studies
MH  - Urotensins/*blood
PMC - PMC8816432
EDAT- 2010/08/11 06:00
MHDA- 2010/12/17 06:00
PMCR- 2010/06/11
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
PHST- 2010/06/11 00:00 [pmc-release]
AID - JCH336 [pii]
AID - 10.1111/j.1751-7176.2010.00336.x [doi]
PST - ppublish
SO  - J Clin Hypertens (Greenwich). 2010 Aug;12(8):653-60. doi: 
      10.1111/j.1751-7176.2010.00336.x.