PMID- 20696770
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20220408
IS  - 1651-1905 (Electronic)
IS  - 1403-4948 (Linking)
VI  - 38
IP  - 7
DP  - 2010 Nov
TI  - Incidence of and risk factors for type-2 diabetes in a general population: the 
      Tromso Study.
PG  - 768-75
LID - 10.1177/1403494810380299 [doi]
AB  - AIMS: To determine the gender-specific incidence and risk factors of type-2 
      diabetes mellitus (T2DM) in a general population. METHODS: The study is based on 
      12,431 men and 13,737 women aged 25-98 years, attending the Tromso Study in 1994 
      and followed through 2005, who did not have diabetes when entering the study. 
      Sex-specific hazard ratios were estimated from Cox proportional hazard models. 
      RESULTS: A total of 522 cases of T2DM were registered, 308 among men and 214 
      among women. The age-standardised incidence rate was higher in men than in women, 
      2.6 (95% CI 2.32-2.90) and 1.6(95% CI 1.40-1.83) per 1000 person-years, 
      respectively. In multivariate survival analysis, age, body mass index 
      (BMI),triglycerides, high-density lipoprotein (HDL) cholesterol, hypertension, 
      family history of diabetes, low education and smoking were independent predictors 
      of T2DM in both genders (p<0.05). Total cholesterol and lack of leisure-time 
      physical activity were independent predictors in men only. We found an 
      interaction between HDL cholesterol and triglyceride levels(p<0.001) and between 
      triglyceride levels and a positive family history of diabetes (p=.04). These 
      interactions were independent of BMI. A positive family history combined with 
      triglycerides in the highest tertile and BMI >25 kg/m(2) conveyed a 10-year risk 
      of T2DM of 10% (95% CI 8-12%) vs. 0.2% (95% CI 0.08-0.31%) for the lowest risk 
      group. CONCLUSIONS: A family history of diabetes, elevated BMI, and high 
      triglyceride levels identifies independent of cardiovascular risk factors, a 
      group with especially high risk of T2DM. [corrected]
FAU - Joseph, Josepha
AU  - Joseph J
AD  - Department of Community Medicine, University of Tromso, Tromso, Norway. 
      josepha.joseph@uit.no
FAU - Svartberg, Johan
AU  - Svartberg J
FAU - Njolstad, Inger
AU  - Njolstad I
FAU - Schirmer, Henrik
AU  - Schirmer H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100809
PL  - Sweden
TA  - Scand J Public Health
JT  - Scandinavian journal of public health
JID - 100883503
RN  - 0 (Triglycerides)
SB  - IM
EIN - Scand J Public Health. 2010 Nov;38(7):776
EIN - Scand J Public Health. 2011 Jun;39(4):442
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Cardiovascular Diseases/etiology
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology/genetics
MH  - Exercise
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Incidence
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Norway/epidemiology
MH  - Prospective Studies
MH  - Risk Factors
MH  - Triglycerides/blood
EDAT- 2010/08/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1403494810380299 [pii]
AID - 10.1177/1403494810380299 [doi]
PST - ppublish
SO  - Scand J Public Health. 2010 Nov;38(7):768-75. doi: 10.1177/1403494810380299. Epub 
      2010 Aug 9.