PMID- 20697762
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20211020
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 29
IP  - 11
DP  - 2010 Nov
TI  - Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene 
      polymorphisms on bone mineral density in postmenopausal women.
PG  - 1285-93
LID - 10.1007/s10067-010-1548-6 [doi]
AB  - The aim of this study is to evaluate the effects of estrogen receptor 1 (ESR1) 
      and vitamin D receptor (VDR) gene polymorphisms on bone mineral density (BMD) in 
      a group of previously untreated osteoporotic women. Effects of demographic, 
      environmental, and hormonal factors were also evaluated in this context. Fifty 
      women who did not have a prior diagnosis or treatment of osteoporosis were 
      compared with 50 nonosteoporotic postmenopausal women. Demographic and 
      morphometric characteristics, medical history, dietary habits, exercise history, 
      and sunlight exposure were recorded. The diagnosis of osteoporosis was made with 
      regard to BMD measurements with DEXA. Blood samples were obtained for serum 
      biochemistry, bone turnover markers, and VDR and ESR1 gene polymorphism analysis. 
      Polymorphic sites of VDR and ESR1 genes were amplified by polymerase chain 
      reaction and examined using restriction fragment length polymorphism. Bb genotype 
      was significantly higher in the osteoporotic group when compared to controls 
      (p=0.022). Each 1 U decrease in the body mass index (BMI) increased the risk of 
      osteoporosis by 8% independent of the genotype. We could not observe a 
      significant effect of ESR1 polymorphism on BMD or osteoporosis risk. The 
      interaction of ApaI and BsmI genotypes were found to be significant (p=0.041) and 
      the AaBb genotype, when corrected for BMI, was shown to increase the risk of 
      osteoporosis five times (p=0.005). However, the results demonstrated 
      insignificant p values when correction for multiple testing was performed with 
      the Bonferroni method in the logistic regression model. A predominance of Bb 
      genotype of the VDR gene was evident in this group of postmenopausal Turkish 
      women. Moreover, the combined genotype AaBb conferred a five times increased risk 
      for osteoporosis when corrected for clinical variables.
FAU - Durusu Tanriover, Mine
AU  - Durusu Tanriover M
AD  - Department of Internal Medicine, Section of General Internal Medicine, Hacettepe 
      University Faculty of Medicine, and Department of Orthopedics and Traumatology, 
      Gazi Mustafa Kemal Public Hospital, 06100, Sihhiye, Ankara, Turkey. 
      mdurusu@hacettepe.edu.tr
FAU - Bora Tatar, Gamze
AU  - Bora Tatar G
FAU - Uluturk, Tenzile Deniz
AU  - Uluturk TD
FAU - Dayangac Erden, Didem
AU  - Dayangac Erden D
FAU - Tanriover, Altug
AU  - Tanriover A
FAU - Kilicarslan, Alpaslan
AU  - Kilicarslan A
FAU - Oz, S Gul
AU  - Oz SG
FAU - Erdem Yurter, Hayat
AU  - Erdem Yurter H
FAU - Sozen, Tumay
AU  - Sozen T
FAU - Sain Guven, Gulay
AU  - Sain Guven G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100810
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Receptors, Calcitriol)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Body Mass Index
MH  - Bone Density
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/diagnosis/*genetics
MH  - *Polymorphism, Genetic
MH  - Postmenopause
MH  - Receptors, Calcitriol/*genetics
MH  - Risk
EDAT- 2010/08/11 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/03/23 00:00 [received]
PHST- 2010/07/26 00:00 [accepted]
PHST- 2010/07/22 00:00 [revised]
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1007/s10067-010-1548-6 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2010 Nov;29(11):1285-93. doi: 10.1007/s10067-010-1548-6. Epub 
      2010 Aug 10.