PMID- 20697938
OWN - NLM
STAT- MEDLINE
DCOM- 20101126
LR  - 20211020
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Aug
TI  - Clinical study on the treatment of knee osteoarthritis of Shen-Sui insufficiency 
      syndrome type by electroacupuncture.
PG  - 291-7
LID - 10.1007/s11655-010-0513-1 [doi]
AB  - OBJECTIVE: To study the clinical effificacy of electroacupuncture (EA) on 
      treating knee osteoarthritis (KOA) of Shen ()-Sui () insuffificiency (SSI) 
      syndrome type. METHODS: A total of 245 patients (279 knees) of KOA-SSI were 
      randomly assigned to two groups by lottery: 141 knees in the treatment group and 
      138 knees in the control group. The treatment group was managed with EA at the 
      dominant points of Neixiyan (Ex-LE4) and Waixiyan (Ex-LE5) as well as the 
      conjugate points of Xuanzhong (GB39) and Taixi (KI3) for 30 min, once a day, with 
      15 days as one course; 2 courses were applied with a 5-day interval in between. 
      The control group was treated with intra-articular injection of 2 mL hyaluronic 
      acid into the affected joint every 7 days for 5 times in total. The clinical 
      effects on the patients in different stages were observed, and their symptom 
      scores of knee and contents of cytokines, including interleukin-1 (IL-1), 
      interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), prostaglandin 
      E(2alpha) (PGE(2alpha)) and matrix metalloproteinases-3 (MMP-3), in the knee 
      joint fluid were measured before and after treatment. RESULTS: The study was 
      completed in 235 patients (263 knees); four patients (7 knees) in the treatment 
      group and six patients (9 knees) in the control group dropped out. Comparison of 
      therapeutic effects (excellent and effective rates) between the two groups showed 
      insignificant differences (P>0.05). Symptom scores of knee and contents of 
      cytokines in the knee flfluid after treatment were lowered signifificantly in the 
      patients of stage I-III in both groups (P<0.05 or P<0.01). However, the lowering 
      of the total symptom score of knee in the patients of stage III in the treatment 
      group was more signifificant (P<0.05). CONCLUSIONS: EA could effectively 
      alleviate the clinical symptoms in KOA patients of stage III, showing an effect 
      superior to that of hyaluronic acid. EA also shows action in suppressing the 
      secretion of IL-1, IL-6, TNF-alpha, PGE(2alpha) and MMP-3 in the knee flfluid.
FAU - Wu, Ming-xia
AU  - Wu MX
AD  - The Second People's Hospital Affiliated to Fujian University of Traditional 
      Chinese Medicine, Fuzhou 350003, China.
FAU - Li, Xi-hai
AU  - Li XH
FAU - Lin, Mu-nan
AU  - Lin MN
FAU - Jia, Xi-rui
AU  - Jia XR
FAU - Mu, Rong
AU  - Mu R
FAU - Wan, Wen-rong
AU  - Wan WR
FAU - Chen, Rui-hua
AU  - Chen RH
FAU - Chen, Li-hua
AU  - Chen LH
FAU - Lin, Wan-qing
AU  - Lin WQ
FAU - Huang, Cong-yang
AU  - Huang CY
FAU - Zhang, Xue-ru
AU  - Zhang XR
FAU - Hong, Kun-da
AU  - Hong KD
FAU - Li, Li
AU  - Li L
FAU - Liu, Xian-xiang
AU  - Liu XX
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100810
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Cytokines)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Cytokines/metabolism
MH  - Electroacupuncture/adverse effects/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Middle Aged
MH  - Osteoarthritis, Knee/diagnostic imaging/enzymology/*therapy
MH  - Radiography
MH  - Syndrome
MH  - Synovial Fluid/enzymology
MH  - Treatment Outcome
EDAT- 2010/08/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/01/15 00:00 [received]
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s11655-010-0513-1 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2010 Aug;16(4):291-7. doi: 10.1007/s11655-010-0513-1. Epub 
      2010 Aug 10.