PMID- 20697948 OWN - NLM STAT- MEDLINE DCOM- 20101126 LR - 20211020 IS - 1993-0402 (Electronic) IS - 1672-0415 (Linking) VI - 16 IP - 4 DP - 2010 Aug TI - Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine. PG - 353-6 LID - 10.1007/s11655-010-0504-2 [doi] AB - OBJECTIVE: To assess the effect and adverse reaction of total glucosides of paeony capsule (TGPC) in combining with citirizine for the treatment of chronic urticaria. METHODS: A total of 120 patients were assigned to two groups by lottery, 65 in the treated group and 55 in the control group. They all were orally treated with citirizine tablet 10 mg per day, but to the treated group, additional 0.2 g TGPC was given three times per day, the therapeutic course for both groups was 4 weeks. The effectiveness of treatment was observed, and the changes of total symptom score, serum levels of interleukin-4 (IL-4), and immunoglobulin E (IgE) were measured before and after treatment. Moreover, a follow-up was carried out one month after ending the treatment. RESULTS: The dropped cases were two in the treated group and seven in the control group; so, the study was accomplished on 63 patients in the treated group and 48 patients in the control group. The total effective rate was assessed at 73.02% (46/63) in the treated group, which was significantly higher than 47.92% (23/48) in the control group (P<0.01). After treatment, the total symptom score decreased in both groups, but the decrement in the treated group was more significant (P<0.05). Serum levels of IL-4 and IgE in the treated group lowered significantly, while the changes in the control group were insignificant, so statistical significant differences were shown between groups (P<0.01). A follow-up study showed that the relapse rate in the treated group was 30.00% (6/20), while that in the control group was 90.00% (9/10), and the former was lower than the latter (P<0.01). Adverse reactions, revealed as drowsiness, dizziness, and weakness, were seen in eight cases and seven cases in the two groups, respectively. Besides, mild diarrhea occurred in two cases of the treated group. CONCLUSIONS: The treatment of TGPC combining citirizine shows definite curative effect in treating chronic urticaria, with low relapse rate and without evident adverse reaction. Its therapeutic effect might be realized by means of regulating patients' immune function. Besides, the medication should be continued for a rather long period to achieve the full effect. FAU - Long, Jian-wen AU - Long JW AD - Union Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China. FAU - Wang, Yu-ying AU - Wang YY FAU - Pi, Xian-ming AU - Pi XM FAU - Tu, Ya-ting AU - Tu YT LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20100810 PL - China TA - Chin J Integr Med JT - Chinese journal of integrative medicine JID - 101181180 RN - 0 (Anti-Allergic Agents) RN - 0 (Capsules) RN - 0 (Glucosides) RN - 207137-56-2 (Interleukin-4) RN - 37341-29-0 (Immunoglobulin E) RN - YO7261ME24 (Cetirizine) SB - IM MH - Adolescent MH - Adult MH - Anti-Allergic Agents/adverse effects/*therapeutic use MH - Capsules MH - Cetirizine/adverse effects/*therapeutic use MH - Chronic Disease MH - Drug Therapy, Combination MH - Female MH - Glucosides/adverse effects/*therapeutic use MH - Humans MH - Immunoglobulin E/blood MH - Interleukin-4/blood MH - Male MH - Middle Aged MH - Paeonia/*chemistry MH - Phytotherapy MH - Recurrence MH - Treatment Outcome MH - Urticaria/blood/*drug therapy MH - Young Adult EDAT- 2010/08/11 06:00 MHDA- 2010/12/14 06:00 CRDT- 2010/08/11 06:00 PHST- 2009/09/14 00:00 [received] PHST- 2010/08/11 06:00 [entrez] PHST- 2010/08/11 06:00 [pubmed] PHST- 2010/12/14 06:00 [medline] AID - 10.1007/s11655-010-0504-2 [doi] PST - ppublish SO - Chin J Integr Med. 2010 Aug;16(4):353-6. doi: 10.1007/s11655-010-0504-2. Epub 2010 Aug 10.