PMID- 20697980
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20220720
IS  - 1534-6293 (Electronic)
IS  - 1528-4042 (Print)
IS  - 1528-4042 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Nov
TI  - Neurologic consequences of the immune reconstitution inflammatory syndrome 
      (IRIS).
PG  - 467-75
LID - 10.1007/s11910-010-0138-y [doi]
AB  - Although major advancements have been made in the treatment of HIV infection, 
      graft-versus-host reactions, and autoimmune diseases, an unexpected consequence 
      of treatment has been the emergence of a devastating inflammatory syndrome, 
      termed the immune reconstitution inflammatory syndrome (IRIS). The 
      pathophysiology of the syndrome is poorly understood, and the syndrome poses 
      unique challenges for diagnosis and treatment. We have reviewed the neurologic 
      manifestations of IRIS in the context of HIV infection as well as in the setting 
      of treatment of autoimmune diseases such as multiple sclerosis, in which 
      compartmental immune suppression may occur without an obvious underlying immune 
      suppression. The purpose of this review is to identify common themes that may 
      assist in the diagnosis and management of these IRIS syndromes.
FAU - McCarthy, Micheline
AU  - McCarthy M
AD  - Department of Neurology, Miller School of Medicine, University of Miami, Miami, 
      FL 33125, USA. mmccarth@med.miami.edu
FAU - Nath, Avindra
AU  - Nath A
LA  - eng
GR  - P30 AI073961/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Neurol Neurosci Rep
JT  - Current neurology and neuroscience reports
JID - 100931790
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - HIV Infections/complications/diagnosis/*drug therapy
MH  - HIV-1
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/complications/*diagnosis/*drug 
      therapy
MH  - Nervous System Diseases/complications/*diagnosis/*drug therapy
MH  - Risk Factors
PMC - PMC9295338
MID - NIHMS1787224
COIS- Disclosure No potential conflicts of interest relevant to this article were 
      reported.
EDAT- 2010/08/11 06:00
MHDA- 2011/01/12 06:00
PMCR- 2022/07/19
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
PHST- 2022/07/19 00:00 [pmc-release]
AID - 10.1007/s11910-010-0138-y [doi]
PST - ppublish
SO  - Curr Neurol Neurosci Rep. 2010 Nov;10(6):467-75. doi: 10.1007/s11910-010-0138-y.