PMID- 20698032
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20211020
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 64
IP  - 10
DP  - 2010 Oct
TI  - (+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning 
      in adrenalectomized rats is independent of hyperthermia.
PG  - 773-85
LID - 10.1002/syn.20784 [doi]
AB  - Methamphetamine (MA) is widely abused and implicated in residual cognitive 
      deficits. In rats, increases in plasma corticosterone and egocentric learning 
      deficits are observed after a 1-day binge regimen of MA (10 mg/kg x 4 at 2-h 
      intervals). The purpose of this experiment was to determine if adrenal 
      inactivation during and following MA exposure would attenuate the egocentric 
      learning deficits in the Cincinnati water maze (CWM). In the first experiment, 
      the effects of adrenalectomy (ADX) or sham surgery (SHAM) on MA-induced 
      neurotoxicity at 72 h were determined. SHAM-MA animals showed typical patterns of 
      hyperthermia, whereas ADX-MA animals were normothermic. Both SHAM-MA- and 
      ADX-MA-treated animals showed increased neostriatal glial fibrillary acidic 
      protein and decreased monoamines in the neostriatum, hippocampus, and entorhinal 
      cortex. In the second experiment, SHAM-MA- and ADX-MA-treated groups showed 
      equivalently impaired CWM performance 2 weeks post-treatment (increased 
      latencies, errors, and start returns) compared to SHAM-saline (SAL) and ADX-SAL 
      groups with no effects on novel object recognition, elevated zero maze, or 
      acoustic startle/prepulse inhibition. Post-testing, monoamine levels remained 
      decreased in both MA-treated groups in all three brain regions, but were not as 
      large as those observed at 72-h post-treatment. The data demonstrate that 
      MA-induced learning deficits can be dissociated from drug-induced increases in 
      plasma corticosterone or hyperthermia, but co-occur with dopamine and serotonin 
      reductions.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Herring, Nicole R
AU  - Herring NR
AD  - Division of Neurology, Cincinnati Children's Research Foundation and University 
      of Cincinnati College of Medicine, Cincinnati, OH, USA.
FAU - Gudelsky, Gary A
AU  - Gudelsky GA
FAU - Vorhees, Charles V
AU  - Vorhees CV
FAU - Williams, Michael T
AU  - Williams MT
LA  - eng
GR  - R01 DA006733/DA/NIDA NIH HHS/United States
GR  - R01 ES015689/ES/NIEHS NIH HHS/United States
GR  - DA006733/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 44RAL3456C (Methamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Adrenalectomy/methods
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Biogenic Monoamines/*metabolism
MH  - Body Temperature/drug effects
MH  - Brain/drug effects/metabolism
MH  - Central Nervous System Stimulants/*adverse effects
MH  - Corticosterone/blood
MH  - Gene Expression Regulation/drug effects
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - *Hyperthermia, Induced
MH  - Learning Disabilities/blood/*chemically induced/physiopathology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Methamphetamine/*adverse effects
MH  - Neural Inhibition/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stereotyped Behavior/drug effects
PMC - PMC2921964
MID - NIHMS189812
EDAT- 2010/08/11 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/10/01
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - 10.1002/syn.20784 [doi]
PST - ppublish
SO  - Synapse. 2010 Oct;64(10):773-85. doi: 10.1002/syn.20784.