PMID- 20698307
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20230202
IS  - 0004-1955 (Print)
IS  - 0004-1955 (Linking)
VI  - 72
IP  - 2
DP  - 2010 Mar-Apr
TI  - [The place of dendritic cells in the microenviroment in Hodgkin's lymphoma].
PG  - 3-7
AB  - Dendritic cells (DCs) are the least studied microenvironment elements in 
      Hodgkin's lymphoma (HL). Ninety-five lymph nodes were morphologically and 
      immunohistochemically studied in patients with classical HL. The authors found 
      CDla- and langerin-positive DCs in the presence of T lymphocytes, which were 
      localized in the close proximity to neoplastic Reed-Sternberg cells (RSCs). There 
      were also CD23-positive follicular DCs, which were typically located at the 
      periphery of tumor foci, in the areas of residual follicular structures, were 
      surrounded by B lymphocytes and were rarely associated with RSCs. There were two 
      morphologically distinct groups among the CD 1a- and langerin-positive DCs; one 
      had developed cytoplasmic processes, which formed a network around the RSCs 
      (probably a more mature/functionally active form); the other had round cells with 
      short cytoplasmic processes, loosely distributed around the neoplastic cells (a 
      less mature/active form). The function and role of CD1a- and langerin-positive 
      DCs in HL call for further investigation. The topographic closeness of these DCs 
      to RSCs suggests that these cells play a considerable role in the pathogenesis of 
      HL.
FAU - Leenman, E E
AU  - Leenman EE
FAU - Mukhina, M S
AU  - Mukhina MS
FAU - Girshovich, M M
AU  - Girshovich MM
FAU - Kanaev, S V
AU  - Kanaev SV
FAU - Konoplev, S N
AU  - Konoplev SN
FAU - Pozharisskii, K M
AU  - Pozharisskii KM
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Arkh Patol
JT  - Arkhiv patologii
JID - 0370604
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
RN  - 0 (CD207 protein, human)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Receptors, IgE)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, CD/immunology
MH  - Antigens, CD1/immunology
MH  - B-Lymphocytes/immunology/pathology
MH  - *Dendritic Cells/immunology/pathology
MH  - *Dendritic Cells, Follicular/immunology/pathology
MH  - Female
MH  - *Hodgkin Disease/immunology/pathology
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Lectins, C-Type/immunology
MH  - *Lymph Nodes/immunology/pathology
MH  - Male
MH  - Mannose-Binding Lectins/immunology
MH  - Middle Aged
MH  - Receptors, IgE/immunology
MH  - *Reed-Sternberg Cells/immunology/pathology
MH  - Retrospective Studies
MH  - T-Lymphocytes/immunology/pathology
EDAT- 2010/08/12 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
PST - ppublish
SO  - Arkh Patol. 2010 Mar-Apr;72(2):3-7.