PMID- 20698842
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20220321
IS  - 1525-1594 (Electronic)
IS  - 0160-564X (Linking)
VI  - 34
IP  - 8
DP  - 2010 Aug
TI  - Application of polycaprolactone as an anti-adhesion biomaterial film.
PG  - 648-53
LID - 10.1111/j.1525-1594.2009.00949.x [doi]
AB  - Adhesions are unavoidable consequences of surgery and other trauma. How to 
      prevent the adhesions remains a big issue in healthcare system. The objective of 
      this study is to test the efficacy of polycaprolactone (PCL) films as physical 
      barriers in reducing postoperative intra-abdominal adhesions in the rat 
      cecum-abdominal wall model. PCL is quite cheap compared with the agents recently 
      used in the market. The fabrication method is also very easy to perform. Scanning 
      electron microscope (SEM) showed multiple pores over upper and bottom surfaces 
      but too small to permit cells to migrate from one surface onto another surface. 
      Those pores were proven to be not interconnected. The PCL film did not show any 
      evidence of cytotoxic effects as it did not induce any significant increase in 
      cytoplasmic lactate dehydrogenase release from the NIH3T3 cells that it came in 
      contact with. In animal studies, the PCL films led to fewer adhesions than 
      Seprafilm in rat adhesion model. PCL films were efficacious in reducing 
      postoperative intra-abdominal adhesion formation in rat cecum-abdominal wall 
      models.
FAU - Lo, Hsien-Yi
AU  - Lo HY
AD  - Institute of Biomedical Engineering, College of Medicine, College of Engineering, 
      National Taiwan University, Taiwan.
FAU - Kuo, Hsuan-Ting
AU  - Kuo HT
FAU - Huang, Yi-You
AU  - Huang YY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Artif Organs
JT  - Artificial organs
JID - 7802778
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyesters)
RN  - 0 (Seprafilm)
RN  - 24980-41-4 (polycaprolactone)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemical synthesis/*therapeutic use/toxicity
MH  - Hyaluronic Acid/therapeutic use
MH  - L-Lactate Dehydrogenase
MH  - Microscopy, Electron, Scanning
MH  - Polyesters/chemical synthesis/*therapeutic use/toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Surface Properties
MH  - Tissue Adhesions/*prevention & control
EDAT- 2010/08/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - AOR949 [pii]
AID - 10.1111/j.1525-1594.2009.00949.x [doi]
PST - ppublish
SO  - Artif Organs. 2010 Aug;34(8):648-53. doi: 10.1111/j.1525-1594.2009.00949.x.