PMID- 20699096
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20220409
IS  - 1096-0945 (Electronic)
IS  - 0014-4800 (Linking)
VI  - 89
IP  - 3
DP  - 2010 Dec
TI  - Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) in non small cell 
      lung cancer.
PG  - 222-6
LID - 10.1016/j.yexmp.2010.08.001 [doi]
AB  - Certain types of human papillomavirus (HPV) induce cancers, especially cervical 
      cancers in women. A meta-analysis of the literature suggests that HPV is also 
      associated with 20%-25% of non small cell lung carcinoma (NSCLC). Merkel cell 
      Polyomavirus (MCPyV) causes most Merkel cell carcinomas in immunocompromised 
      hosts, and is associated with some squamous carcinomas of skin in immunocompetent 
      individuals. Since both oncogenic viruses appear to involve the tonsils and, 
      therefore, have clear access to the lungs, we examined that the possible 
      association of HPV and MCPyV infections with lung cancers, especially, NSCLC. 
      DNAs were extracted from 51 frozen tissues from 30 lung cancer patients, and 
      examined for the presence of HPV and MCPyV by PCR and DNA sequencing analysis. 
      Clinical data was correlated with the viral status. HPVs were only detected in 5 
      adenocarcinomas (16.7% of all lung cancers examined). Three were positive for 
      HPV-16, 1 for HPV-11 and 1 had an unknown HPV type DNA. None was identified in 
      benign tissue. MCPyV DNA was detected in 5 NSCLCs (16.7%). Three of the 5 were 
      identified in squamous carcinomas, 1 in adenocarcinoma, and 1 in an unspecified 
      NSCLC. Two additional samples were positive for MCPyV DNA within benign adjacent 
      lung tissue only. In one adenocarcinoma, HPV-11 was identified in an 
      adenocarcinoma, and MCPyV DNA was detected in the adjacent "benign" tissue. HPV 
      and MCPyV were directly associated with 33.3% of NSCLC. Further studies are 
      necessary to determine if polyomavirus and papillomavirus are necessary risk 
      factors for some cases of NSCLC.
CI  - Copyright (c) 2010. Published by Elsevier Inc.
FAU - Joh, Joongho
AU  - Joh J
AD  - James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, 
      USA.
FAU - Jenson, A Bennett
AU  - Jenson AB
FAU - Moore, Grace D
AU  - Moore GD
FAU - Rezazedeh, Arash
AU  - Rezazedeh A
FAU - Slone, Stephen P
AU  - Slone SP
FAU - Ghim, Shin-je
AU  - Ghim SJ
FAU - Kloecker, Goetz H
AU  - Kloecker GH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100807
PL  - Netherlands
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*virology
MH  - DNA, Viral/analysis/isolation & purification
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*virology
MH  - Male
MH  - Middle Aged
MH  - Papillomaviridae
MH  - Papillomavirus Infections/*complications/epidemiology
MH  - Polymerase Chain Reaction
MH  - Polyomavirus
MH  - Polyomavirus Infections/*complications/epidemiology
EDAT- 2010/08/12 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/07/31 00:00 [received]
PHST- 2010/08/02 00:00 [accepted]
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - S0014-4800(10)00107-3 [pii]
AID - 10.1016/j.yexmp.2010.08.001 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 2010 Dec;89(3):222-6. doi: 10.1016/j.yexmp.2010.08.001. Epub 2010 
      Aug 7.