PMID- 20699660
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20211203
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 9
IP  - 15
DP  - 2010 Aug 1
TI  - Fine-tuning CD8(+) T cell functional responses: mTOR acts as a rheostat for 
      regulating CD8(+) T cell proliferation, survival and differentiation?
PG  - 2996-3001
LID - 10.4161/cc.9.15.12359 [doi]
AB  - Naive CD8(+) T cells are instructed by antigen, co-stimulatory molecules and 
      cytokines to undergo proliferation, clonal expansion and differentiation for 
      effector and memory functions. The integration of extracellular instructions 
      induces coordinated signaling cascades and transcriptional programs to determine 
      CD8(+) T cell functional fate. Although, an important role for the energy 
      sensitive kinase-mammalian target of rapamycin (mTOR) in regulating T cell 
      proliferation and cell survival instep with cellular metabolic status has been 
      demonstrated, emerging information indicates that mTOR also acts as a critical 
      regulator of effector and memory functional fates in CD8(+) T cells. Herein, we 
      discuss the pathways by which cellular metabolism regulates proliferation, 
      survival and functional differentiation of CD8(+) T cells and focus on the role 
      of mTOR as the rheostat that strikes a balance between effector and memory 
      differentiation of CD8(+) T cells for enabling adaptive host immunity.
FAU - Rao, Rajesh R
AU  - Rao RR
AD  - Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA.
FAU - Li, Qingsheng
AU  - Li Q
FAU - Shrikant, Protul A
AU  - Shrikant PA
LA  - eng
PT  - Journal Article
DEP - 20100812
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/*cytology/*metabolism
MH  - Cell Cycle
MH  - *Cell Differentiation/genetics
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Humans
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - Signal Transduction
MH  - Sirtuins/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Transcription, Genetic
EDAT- 2010/08/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 12359 [pii]
AID - 10.4161/cc.9.15.12359 [doi]
PST - ppublish
SO  - Cell Cycle. 2010 Aug 1;9(15):2996-3001. doi: 10.4161/cc.9.15.12359. Epub 2010 Aug 
      12.