PMID- 20701788
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20221207
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 9
DP  - 2010 Aug 11
TI  - KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han 
      population.
PG  - 35
LID - 10.1186/1475-2840-9-35 [doi]
AB  - BACKGROUND: Four single nucleotide polymorphisms (SNPs) (rs2237892, rs2237895, 
      rs2237897, and rs2283228) in KCNQ1 are reported to be associated with type 2 
      diabetes mellitus (T2DM), possibly caused by a reduction in insulin secretion and 
      higher fasting glucose, but the results are inconsistent. We investigated whether 
      these 4 genetic markers are associated with serum lipid metabolism in a 
      middle-aged Chinese Han population. METHODS: We enrolled 398 consecutive 
      patients, including 180 with premature coronary artery disease (CAD) (male < 55 
      years, female < 65 years) and 218 controls without documented CAD. All subjects 
      were genotyped for 4 SNPs by using the ligase detection reaction method. Fasting 
      blood sugar (FBS) and plasma concentrations of total cholesterol, triglycerides 
      (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein 
      cholesterol (LDL-C), apolipoprotein A1(apo A1), and apolipoprotein B (apo B) were 
      determined by standard biochemical methods. Main anthropometric and metabolic 
      characteristics are analyzed among 3 genotypes at rs2283228, rs2237895, 
      rs2237897, or rs2237892 in KCNQ1. RESULTS: The 3 genotypes AA, AC, and CC were 
      present in rs2283228 and rs2237895, and the 3 genotypes CC, CT, and TT were 
      present in rs2237897 and rs2237892. The minor genotypes CC at rs2283228 and TT at 
      rs2237892 were associated with higher levels of TG (P = 0.007 and 0.026, 
      respectively). Furthermore, subjects with the CC genotype at rs2283228 had lower 
      levels of HDL-C and apo A1 than in the other 2 genotype groups (P = 0.052 and 
      0.055, respectively). No other associations were detected between these 4 SNPs 
      and FBS or other lipid parameters. CONCLUSIONS: Our data suggest that rs2283228 
      and rs2237892 in KCNQ1 are associated with lipid metabolism in a middle-aged 
      Chinese Han population.
FAU - Chen, Zhong
AU  - Chen Z
AD  - Department of Cardiology, the Affiliated ZhongDa Hospital and Institute of 
      Cardiovascular Disease of Southeast University, Nanjing 210009, PR China. 
      zhongchen7498@sina.com
FAU - Yin, Quanzhong
AU  - Yin Q
FAU - Ma, Genshan
AU  - Ma G
FAU - Qian, Qi
AU  - Qian Q
LA  - eng
PT  - Journal Article
DEP - 20100811
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (KCNQ1 Potassium Channel)
RN  - 0 (KCNQ1 protein, human)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics/statistics & numerical data
MH  - China/epidemiology
MH  - Coronary Artery Disease/ethnology/*genetics/metabolism
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics/metabolism
MH  - Dyslipidemias/ethnology/*genetics/metabolism
MH  - Female
MH  - Genotype
MH  - Homeostasis/genetics
MH  - Humans
MH  - KCNQ1 Potassium Channel/*genetics
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC2925337
EDAT- 2010/08/13 06:00
MHDA- 2010/12/14 06:00
PMCR- 2010/08/11
CRDT- 2010/08/13 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2010/08/11 00:00 [accepted]
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2010/08/11 00:00 [pmc-release]
AID - 1475-2840-9-35 [pii]
AID - 10.1186/1475-2840-9-35 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2010 Aug 11;9:35. doi: 10.1186/1475-2840-9-35.