PMID- 20704608
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20131121
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - High-dose unfractionated heparin therapy in a pregnant patient with 
      antiphospolipid syndrome: a case report.
PG  - e32-5
LID - 10.1111/j.1756-185X.2010.01484.x [doi]
AB  - A case of a 37-year-old pregnant patient with antiphospholipid syndrome (APS), 
      who has a medical history of both thrombosis and recurrent fetal loss, is 
      presented. She was treated with predonisolone and fixed-dose unfractionated 
      heparin (UFH) infusion, followed by plasmaphereses and fixed-dose 
      low-molecular-weight heparin infusion during her fourth pregnancy. Unfortunately, 
      this treatment did not have beneficial effects, resulting in intrauterine growth 
      restriction and finally neonatal death. Continuous intravenous UFH infusion and 
      low-dose aspirin were administrated under the monitoring of the activated partial 
      thromboplastin time to achieve a target level of 120 s during her fifth 
      pregnancy. A healthy baby weighing 1818 g at birth was delivered by Cesarean 
      section at the 34th week of pregnancy. High-dose UFH infusion may be considered 
      to be one of the preferable options to manage pregnant patients with refractory 
      APS.
FAU - Ogishima, Hiroshi
AU  - Ogishima H
AD  - Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate 
      School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 
      Japan. ogishima@md.tsukuba.ac.jp
FAU - Ito, Satoshi
AU  - Ito S
FAU - Tsutsumi, Akito
AU  - Tsutsumi A
FAU - Sugihara, Makoto
AU  - Sugihara M
FAU - Goto, Daisuke
AU  - Goto D
FAU - Matsumoto, Isao
AU  - Matsumoto I
FAU - Obata-Yasuoka, Mana
AU  - Obata-Yasuoka M
FAU - Hamada, Hiromi
AU  - Hamada H
FAU - Yoshikawa, Hiroyuki
AU  - Yoshikawa H
FAU - Takahashi, Hideto
AU  - Takahashi H
FAU - Murashima, Atsuko
AU  - Murashima A
FAU - Sumida, Takayuki
AU  - Sumida T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Anticoagulants/*administration & dosage
MH  - Antiphospholipid Syndrome/blood/*drug therapy
MH  - Aspirin/administration & dosage
MH  - Blood Coagulation/*drug effects
MH  - Cesarean Section
MH  - Drug Monitoring/methods
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fetal Death/prevention & control
MH  - Heparin/*administration & dosage
MH  - Humans
MH  - Infusions, Intravenous
MH  - Live Birth
MH  - Partial Thromboplastin Time
MH  - Pregnancy
MH  - Pregnancy Complications/blood/*drug therapy
MH  - Pregnancy, High-Risk
MH  - Treatment Outcome
EDAT- 2010/08/14 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - APL1484 [pii]
AID - 10.1111/j.1756-185X.2010.01484.x [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2010 Aug;13(3):e32-5. doi: 10.1111/j.1756-185X.2010.01484.x.