PMID- 20704908
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20100813
IS  - 1944-7930 (Electronic)
IS  - 1539-6509 (Linking)
VI  - 5
IP  - 26
DP  - 2005 Apr
TI  - Preventing autoimmune diabetes through gene therapy.
PG  - 186-90
AB  - Extract: Type 1 diabetes is an autoimmune disease in which an individual develops 
      T cells that are able to destroy insulin-producing beta cells in the pancreas. 
      Type 1 diabetics require life-long treatment with exogenous insulin for survival. 
      Susceptibility to type 1 diabetes is influenced by both genetic and environmental 
      factors. The first diabetes-susceptibility genes to be identified were the human 
      leukocyte antigen (HLA) genes. Subsequent studies demonstrated an association of 
      these genes with the insulin gene region. High throughput screening of the human 
      genome in families with two or more affected siblings led to the identification 
      of additional chromosomal regions that may contain susceptibility genes for type 
      1 diabetes. However, linkage between the HLA gene region and susceptibility to 
      disease suggested that the principal genetic component leading to development of 
      diabetes is the inheritance of mutant HLA class II alleles. These are so-called 
      "at-risk" alleles which lack an aspartic acid, a positively amino acid, at 
      position 57 of the major histocompatibility complex (MHC) class II beta chain.
FAU - Tian, Chaorui
AU  - Tian C
AD  - Transplantation Research Center, Brigham and Women's Hospital and Children's 
      Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
FAU - Bagley, Jessamyn
AU  - Bagley J
FAU - Iacomini, John
AU  - Iacomini J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Discov Med
JT  - Discovery medicine
JID - 101250006
EDAT- 2005/04/01 00:00
MHDA- 2005/04/01 00:01
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2005/04/01 00:00 [pubmed]
PHST- 2005/04/01 00:01 [medline]
PST - ppublish
SO  - Discov Med. 2005 Apr;5(26):186-90.