PMID- 20704910 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20100813 IS - 1944-7930 (Electronic) IS - 1539-6509 (Linking) VI - 5 IP - 26 DP - 2005 Apr TI - Lactobacilli as natural enhancer of cellular immune response. PG - 199-203 AB - Extract: Dendritic cells (DCs), widely distributed in lymphoid (containing lymphocytes) and non-lymphoid tissue, are a complex, heterogeneous group of multifunctional antigen-presenting cells that comprise an essential component of the immune system. For well over a decade, dendritic cells have been recognized as an essential component of both the host innate and adaptive immune responses. DCs, due to their differential regulation and initiation of acquired immune responses, are at the forefront of current research in immunobiology and vaccinology. Recent reports suggest that certain types of antigens (a substance capable of inducing an immune response) differentially govern DC activation and maturation, which ultimately influence the entire immune response. Various species of Lactobacillus (a bacterium found ubiquitously in the mouth, intestinal tract, and vagina) have been shown to differentially regulate dendritic cells and enhance their ability to prime specific immune responses and, thus, they may have great utility as future vaccine adjuvants. FAU - Kalina, Warren V AU - Kalina WV AD - U.S. Army Research Institute of Infectious Diseases, Frederick, MD 21702, USA. FAU - Mohamadzadeh, Mansour AU - Mohamadzadeh M LA - eng PT - Journal Article PL - United States TA - Discov Med JT - Discovery medicine JID - 101250006 EDAT- 2005/04/01 00:00 MHDA- 2005/04/01 00:01 CRDT- 2010/08/14 06:00 PHST- 2010/08/14 06:00 [entrez] PHST- 2005/04/01 00:00 [pubmed] PHST- 2005/04/01 00:01 [medline] PST - ppublish SO - Discov Med. 2005 Apr;5(26):199-203.