PMID- 20705860
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20211020
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 329
IP  - 5993
DP  - 2010 Aug 13
TI  - Activation of beta-catenin in dendritic cells regulates immunity versus tolerance 
      in the intestine.
PG  - 849-53
LID - 10.1126/science.1188510 [doi]
AB  - Dendritic cells (DCs) play a vital role in initiating robust immunity against 
      pathogens as well as maintaining immunological tolerance to self antigens. 
      However, the intracellular signaling networks that program DCs to become 
      tolerogenic remain unknown. We report here that the Wnt-beta-catenin signaling in 
      intestinal dendritic cells regulates the balance between inflammatory versus 
      regulatory responses in the gut. beta-catenin in intestinal dendritic cells was 
      required for the expression of anti-inflammatory mediators such as retinoic 
      acid-metabolizing enzymes, interleukin-10, and transforming growth factor-beta, 
      and the stimulation of regulatory T cell induction while suppressing inflammatory 
      effector T cells. Furthermore, ablation of beta-catenin expression in DCs 
      enhanced inflammatory responses and disease in a mouse model of inflammatory 
      bowel disease. Thus, beta-catenin signaling programs DCs to a tolerogenic state, 
      limiting the inflammatory response.
FAU - Manicassamy, Santhakumar
AU  - Manicassamy S
AD  - Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood 
      Road, Atlanta, GA 30329, USA.
FAU - Reizis, Boris
AU  - Reizis B
FAU - Ravindran, Rajesh
AU  - Ravindran R
FAU - Nakaya, Helder
AU  - Nakaya H
FAU - Salazar-Gonzalez, Rosa Maria
AU  - Salazar-Gonzalez RM
FAU - Wang, Yi-Chong
AU  - Wang YC
FAU - Pulendran, Bali
AU  - Pulendran B
LA  - eng
SI  - GEO/GSE2213
GR  - R37 AI048638/AI/NIAID NIH HHS/United States
GR  - HHSN266200700006C/AI/NIAID NIH HHS/United States
GR  - N01 AI50019/AI/NIAID NIH HHS/United States
GR  - N01AI50025/AI/NIAID NIH HHS/United States
GR  - R37AI48638,/AI/NIAID NIH HHS/United States
GR  - U19 AI057266/AI/NIAID NIH HHS/United States
GR  - R01 DK057665/DK/NIDDK NIH HHS/United States
GR  - U19AI057266,/AI/NIAID NIH HHS/United States
GR  - U54AI057157/AI/NIAID NIH HHS/United States
GR  - R37 DK057665/DK/NIDDK NIH HHS/United States
GR  - R01 AI048638/AI/NIAID NIH HHS/United States
GR  - HHSN266 200700006C/PHS HHS/United States
GR  - R01DK057665,/DK/NIDDK NIH HHS/United States
GR  - N01AI50019/AI/NIAID NIH HHS/United States
GR  - R01 AI056499/AI/NIAID NIH HHS/United States
GR  - N01 AI50025/AI/NIAID NIH HHS/United States
GR  - U54 AI057157/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (CTNNB1 protein, mouse)
RN  - 0 (Cytokines)
RN  - 0 (Wnt Proteins)
RN  - 0 (beta Catenin)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
EIN - Science. 2011 Nov 4;334(6056):594
CIN - Science. 2010 Aug 13;329(5993):767-9. PMID: 20705838
CIN - Nat Rev Immunol. 2010 Oct;10(10):682. PMID: 20879170
CIN - Immunotherapy. 2011 Mar;3(3):314-6. PMID: 21516876
CIN - Science. 2011 Jul 22;333(6041):405; author reply 405. PMID: 21778384
MH  - Animals
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Gene Expression Profiling
MH  - *Inflammation
MH  - Inflammatory Bowel Diseases/*immunology
MH  - Intestinal Mucosa/cytology/*immunology/metabolism
MH  - Macrophages/immunology/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Oligonucleotide Array Sequence Analysis
MH  - *Self Tolerance
MH  - Signal Transduction
MH  - T-Lymphocytes, Helper-Inducer/cytology/*immunology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Tretinoin/metabolism
MH  - Wnt Proteins/metabolism
MH  - beta Catenin/*metabolism
PMC - PMC3732486
MID - NIHMS494956
EDAT- 2010/08/14 06:00
MHDA- 2010/08/25 06:00
PMCR- 2013/08/03
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
PHST- 2013/08/03 00:00 [pmc-release]
AID - 329/5993/849 [pii]
AID - 10.1126/science.1188510 [doi]
PST - ppublish
SO  - Science. 2010 Aug 13;329(5993):849-53. doi: 10.1126/science.1188510.