PMID- 20705913
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Print)
IS  - 1079-5642 (Linking)
VI  - 30
IP  - 11
DP  - 2010 Nov
TI  - Increased atherosclerosis in mice with vascular ATP-binding cassette transporter 
      G1 deficiency--brief report.
PG  - 2103-5
LID - 10.1161/ATVBAHA.110.212985 [doi]
AB  - OBJECTIVE: The objective of this study was to investigate the role of vascular 
      ATP-binding cassette transporter G1 (ABCG1) in atherogenesis without a 
      confounding difference in macrophage ABCG1 expression. ABCG1 is highly expressed 
      in macrophages and endothelial cells. ABCG1 preserves endothelial function by 
      maintaining endothelial NO synthase activity and by reducing adhesion molecule 
      expression and monocyte adhesion. METHODS AND RESULTS: To investigate the role of 
      vascular ABCG1 in atherosclerosis in vivo Abcg1(-/-)/Ldlr(-/-) and Ldlr(-/-) mice 
      were transplanted with wild-type bone marrow and fed a Western-type diet for 12 
      or 23 weeks. The atherosclerotic lesion area was similar in both groups after 12 
      weeks but was increased in Abcg1(-/-)/Ldlr(-/-) recipients after 23 weeks, 
      especially in the aortic arch (2.2-fold; P<0.01). Endothelial NO 
      synthase-mediated vascular relaxation was impaired in male Abcg1(-/-)/Ldlr(-/-) 
      recipients. CONCLUSIONS: Our data show an atheroprotective role of vascular 
      ABCG1, especially in the aortic arch, likely related to its role in the 
      preservation of endothelial NO synthase activity.
FAU - Westerterp, Marit
AU  - Westerterp M
AD  - Division of Molecular Medicine, Department of Medicine, Columbia University, New 
      York, NY 10032, USA.
FAU - Koetsveld, Joris
AU  - Koetsveld J
FAU - Yu, Shuiqing
AU  - Yu S
FAU - Han, Seongah
AU  - Han S
FAU - Li, Rong
AU  - Li R
FAU - Goldberg, Ira J
AU  - Goldberg IJ
FAU - Welch, Carrie L
AU  - Welch CL
FAU - Tall, Alan R
AU  - Tall AR
LA  - eng
GR  - R01 HL102395/HL/NHLBI NIH HHS/United States
GR  - HL102395/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100812
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (ABCG1 protein, mouse)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Lipoproteins)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1
MH  - ATP-Binding Cassette Transporters/metabolism
MH  - Animals
MH  - Aorta/metabolism/physiopathology
MH  - Atherosclerosis/*metabolism
MH  - Disease Models, Animal
MH  - Lipoproteins/*deficiency/metabolism
MH  - Mice
PMC - PMC3116721
MID - NIHMS237085
EDAT- 2010/08/14 06:00
MHDA- 2010/12/21 06:00
PMCR- 2011/11/01
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - ATVBAHA.110.212985 [pii]
AID - 10.1161/ATVBAHA.110.212985 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2103-5. doi: 
      10.1161/ATVBAHA.110.212985. Epub 2010 Aug 12.