PMID- 20706023
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20211020
IS  - 1976-555X (Electronic)
IS  - 1229-845X (Print)
IS  - 1229-845X (Linking)
VI  - 11
IP  - 3
DP  - 2010 Sep
TI  - Distribution and characterization of IL-10-secreting cells in lymphoid tissues of 
      PCV2-infected pigs.
PG  - 177-83
AB  - Distribution and characterization of interlukin-10 (IL-10)-secreting cells in 
      lymphoid tissues of pigs naturally infected with porcine circovirus type 2 (PCV2) 
      were evaluated in accordance with PCV2 antigen detection. After screening a total 
      of 56 pigs showing the symptoms of postweaning multisystemic wasting syndrome 
      (PMWS), 15 pigs were PCV2 positive and 5 pigs, which showed stronger positive 
      signals over multiples tissues were further investigated. This study showed that 
      in PCV2-infected lymphoid tissues, particularly mandibular lymph node, spleen and 
      tonsil, IL-10 expression was mainly localized in T-cell rich areas but rarely in 
      B cell rich areas. IL-10 was highly expressed in bystander cells but rarely in 
      PCV2-infected cells. Elevated IL-10 expression was predominantly associated with 
      T cells, but rarely with B cells or with macrophages. The results of this study 
      provide evidence for the role of IL-10 in chronic PCV2 infection and its relation 
      to PCV2 antigen in affected tissues. Constantly elevated levels of IL-10 lead to 
      immunosuppression in persistent and chronic viral infections. The increased IL-10 
      expression observed in PCV2 infection in this study suggests that IL-10-mediated 
      immunosuppression may play an important role in the pathogenesis and maintenance 
      of naturally occurring PCV2 infection.
FAU - Doster, Alan R
AU  - Doster AR
AD  - School of Veterinary Medicine and Biomedical Sciences, University of 
      Nebraska-Lincoln, Lincoln, Nebraska 68583, USA.
FAU - Subramaniam, Sakthivel
AU  - Subramaniam S
FAU - Yhee, Ji Young
AU  - Yhee JY
FAU - Kwon, Byung Joon
AU  - Kwon BJ
FAU - Yu, Chi Ho
AU  - Yu CH
FAU - Kwon, So Young
AU  - Kwon SY
FAU - Osorio, Fernando A
AU  - Osorio FA
FAU - Sur, Jung Hyang
AU  - Sur JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Vet Sci
JT  - Journal of veterinary science
JID - 100964185
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Circoviridae Infections/immunology/pathology/*veterinary
MH  - Circovirus/*immunology
MH  - Gene Expression Regulation/*immunology
MH  - Immunohistochemistry/veterinary
MH  - Interleukin-10/immunology/*metabolism
MH  - Lymphoid Tissue/immunology/metabolism/*pathology
MH  - Porcine Postweaning Multisystemic Wasting Syndrome/*immunology/pathology
MH  - Republic of Korea
MH  - Swine
MH  - T-Lymphocytes/immunology
PMC - PMC2924477
EDAT- 2010/08/14 06:00
MHDA- 2010/12/14 06:00
PMCR- 2010/09/01
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - 201009177 [pii]
AID - 10.4142/jvs.2010.11.3.177 [doi]
PST - ppublish
SO  - J Vet Sci. 2010 Sep;11(3):177-83. doi: 10.4142/jvs.2010.11.3.177.