PMID- 20706040
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20161125
IS  - 1536-0229 (Electronic)
IS  - 0363-9762 (Linking)
VI  - 35
IP  - 9
DP  - 2010 Sep
TI  - A correlative study of FDG PET, MRI/CT, electroencephalography, and clinical 
      features in subacute sclerosing panencephalitis.
PG  - 675-81
LID - 10.1097/RLU.0b013e3181e9fa5f [doi]
AB  - OBJECTIVE: To describe F-18 fluorodeoxyglucose positron emission tomography (FDG 
      PET) profile in patients with subacute sclerosing panencephalitis (SSPE) and to 
      investigate its possible correlation with clinical, electroencephalography (EEG) 
      or magnetic resonance imaging/computed tomography (MRI/CT) findings. METHODS: EEG 
      recording, MRI/CT and FDG PET imaging were performed in 16 patients with SSPE 
      (1.9-15.6 years). FDG PET scans were assessed visually and in standardized uptake 
      values. Finally, all the findings including clinical data were compared. RESULTS: 
      MRI was abnormal in 10 patients. It was normal in 6 of 10 patients in earlier 
      clinical stages. Nonspecific T2-weighted white matter findings were the most 
      consistent MRI finding (10 patients). No thalamic lesion was detected in MRI/CT. 
      FDG PET imaging was abnormal in 14 patients (8/10 patients in earlier stages). 
      Glucose metabolism was decreased in thalamus, cerebellum or cerebral cortex in 
      12, 12, and 9 patients, respectively. Frontal cortex metabolism was preserved in 
      earlier clinical stages. FDG PET imaging revealed putaminal hypermetabolism in 7 
      patients. However, MRI indicated striatal abnormality only in 2 patients with 
      prolonged disease and later clinical stage. Three patients with putaminal 
      hypermetabolism experienced a more rapid clinical deterioration. Onset age of 
      SSPE, age of measles infection and EEG findings were not correlated with the 
      imaging findings. CONCLUSIONS: Our findings suggest that FDG PET imaging can 
      indicate affected brain regions in SSPE more confidently and earlier than MRI. 
      FDG PET imaging would provide new insights into the pathogenesis of SSPE and help 
      to develop new approaches to the patients with SSPE.
FAU - Yilmaz, Kutluhan
AU  - Yilmaz K
AD  - Department of Pediatrics, Gaziantep University, Gaziantep, Turkey. 
      drkutluhan@yahoo.com
FAU - Yilmaz, Mustafa
AU  - Yilmaz M
FAU - Mete, Ahmet
AU  - Mete A
FAU - Celen, Zeki
AU  - Celen Z
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Clin Nucl Med
JT  - Clinical nuclear medicine
JID - 7611109
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Electroencephalography
MH  - Female
MH  - *Fluorodeoxyglucose F18/pharmacokinetics
MH  - Humans
MH  - Infant
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - *Positron-Emission Tomography
MH  - Subacute Sclerosing Panencephalitis/*diagnostic imaging
MH  - *Tomography, X-Ray Computed
EDAT- 2010/08/14 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 00003072-201009000-00003 [pii]
AID - 10.1097/RLU.0b013e3181e9fa5f [doi]
PST - ppublish
SO  - Clin Nucl Med. 2010 Sep;35(9):675-81. doi: 10.1097/RLU.0b013e3181e9fa5f.