PMID- 20706747
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20211020
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 117
IP  - 10
DP  - 2010 Oct
TI  - Environmental enrichment increases the in vivo extracellular concentration of 
      dopamine in the nucleus accumbens: a microdialysis study.
PG  - 1123-30
LID - 10.1007/s00702-010-0447-y [doi]
AB  - The present study was designed to elucidate the effects of environmental 
      enrichment in adulthood (EE) on the in vivo basal and stimulated extracellular 
      concentration of dopamine in the nucleus accumbens of awake rats. The effects of 
      EE on novelty-induced motor activity in an open field and on the levels of 
      brain-derived neurotrophic factor (BDNF) in the nucleus accumbens and striatum 
      were also analysed. Male Wistar rats (3 months of age) were housed in enriched or 
      control conditions during 12 months. After behavioural testing, animals were 
      subdivided in two groups. In one of the groups, BDNF protein levels were 
      determined. In the second group of rats, microdialysis experiments were performed 
      to monitor dialysate concentrations of dopamine in the nucleus accumbens after 
      the perfusion of the glutamatergic agonist 
      alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA; 100 muM) or potassium 
      (100 mM). Both basal and potassium stimulated dialysate concentrations of 
      dopamine were higher in EE than in control rats (basal: 80%; potassium: 210%). EE 
      did not significantly change the increases of dialysate concentrations of 
      dopamine induced by AMPA although there was a trend towards an enhancement of the 
      effects of AMPA. EE decreased novelty-induced locomotor activity but did not 
      modify the levels of BDNF in the nucleus accumbens or in the striatum. These 
      results suggest that the in vivo activity of the mesolimbic dopamine system is 
      enhanced by housing rats in an enriched environment and that this effect is not 
      mediated by BDNF. These findings may be relevant for the understanding of the 
      effects of EE on motor behaviour.
FAU - Segovia, Gregorio
AU  - Segovia G
AD  - Department of Physiology, Faculty of Medicine, Universidad Complutense, Ciudad 
      Universitaria, s/n, 28040 Madrid, Spain. segoviag@med.ucm.es
FAU - Del Arco, Alberto
AU  - Del Arco A
FAU - De Blas, Marta
AU  - De Blas M
FAU - Garrido, Pedro
AU  - Garrido P
FAU - Mora, Francisco
AU  - Mora F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100813
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dopamine/*metabolism
MH  - *Environment
MH  - Extracellular Fluid/*metabolism
MH  - Male
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2010/08/14 06:00
MHDA- 2011/11/10 06:00
CRDT- 2010/08/14 06:00
PHST- 2010/01/29 00:00 [received]
PHST- 2010/07/09 00:00 [accepted]
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1007/s00702-010-0447-y [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2010 Oct;117(10):1123-30. doi: 
      10.1007/s00702-010-0447-y. Epub 2010 Aug 13.