PMID- 20707290
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20151119
IS  - 1128-3602 (Print)
IS  - 1128-3602 (Linking)
VI  - 14
IP  - 8
DP  - 2010 Aug
TI  - Predictors of survival in idiopathic interstitial pneumonia.
PG  - 695-704
AB  - AIM: To evaluate the ability of newly identified clinical factors to predict 
      prognosis and survival in idiopathic pulmonary fibrosis (IPF) and non-specific 
      interstitial pneumonia (NSIP). METHODS: Seventy-eight patients referred to the 
      University of Genoa and the Regional Hospital of Aosta between January 1995 and 
      December 2006 were evaluated prospectively. Fifty-nine patients were diagnosed 
      with IPF and 19 with NSIP on the basis of surgical lung biopsy specimens. Gender, 
      age at diagnosis, smoking, New York Heart Association class (NYHA), systolic 
      pulmonary artery pressure (sPAP), Octreoscan uptake index (UI), and therapy were 
      the chosen variables. Primary end-point was survival. RESULTS: With the exception 
      of gender and smoking history, all baseline patient characteristics correlated 
      significantly with the diagnosis (IPF vs. NSIP). Median survival for the entire 
      study group was 52.7 months. Univariate analysis showed poorer survival for the 
      IPF group versus the NSIP group, and survival was significantly lower for older 
      patients (p < 0.001). Multivariate analysis confirmed the negative prognostic 
      effect of age (p < 0.001) on survival with a risk of death for older patients ( > 
      OR =66 years old) being more than 4 times higher than that for younger patients 
      (<58 yr.). NYHA class and pulmonary artery pressure were also significant 
      predictors of survival, and all patients with a sPAP < OR = 35-mm Hg were alive 
      at the end of the follow-up period. There was a good correlation between 
      Octreoscan uptake index and the diagnosis. CONCLUSION: Diagnosis (IPF vs. NSIP), 
      NYHA class, sPAP, and especially age appear to represent important prognostic 
      indicators in the two most prevalent forms of idiopathic pulmonary fibrosis (IPF 
      and NSIP). Lower Octreoscan uptake values were found in all patients with IPF, 
      suggesting that this test may have a role as a new predictor of survival for 
      differentiating IPF from NSIP.
FAU - Carbone, R
AU  - Carbone R
AD  - Department of Medicine, Respiratory Unit, Regional Hospital Aosta, Aosta, Italy.
FAU - Bottino, G
AU  - Bottino G
FAU - Paredi, P
AU  - Paredi P
FAU - Shah, P
AU  - Shah P
FAU - Meyer, K C
AU  - Meyer KC
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Indium Radioisotopes)
RN  - 51110-01-1 (Somatostatin)
RN  - G083B71P98 (pentetreotide)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Female
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/diagnosis/*mortality/physiopathology
MH  - Indium Radioisotopes
MH  - Lung Diseases, Interstitial/diagnosis/*mortality/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Somatostatin/*analogs & derivatives
MH  - Survival Analysis
EDAT- 2010/08/17 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2010 Aug;14(8):695-704.